Trimethobenzamide (Intramuscular)

Trimethobenzamide is used to treat nausea and vomiting.

This medicine is available only with your doctor's prescription.

Trimethobenzamide will increase the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicines for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicines; prescription pain medicines or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these medicines while you are using trimethobenzamide.

This medicine may make some people feel dizzy, lightheaded, drowsy, or less alert than usual. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

In deciding to use this medicine, you and your doctor need to think about the risks and benefits. Here are some important points to consider:

Allergies

Let your doctor know if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also inform your healthcare professional about any other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

There is no information about how intramuscular trimethobenzamide affects children. However, due to the risks of this medication, it should never be used in children.

Geriatric

There is no information on whether older adults face a higher risk of side effects from trimethobenzamide. However, because of the risks associated with this medication, it should be used carefully in elderly patients, especially after considering other safer options that may not have worked. Recommended doses should not be exceeded, and the patient should be monitored closely during treatment.

Breast Feeding

There are no adequate studies to determine the risks to infants when this medication is used during breastfeeding. Consider the potential benefits and risks before using this medicine while breastfeeding.

Interactions with Medicines

Some medicines should not be used together, while in other cases, two different medicines can be used together even if an interaction might happen. In these situations, your doctor may need to adjust the dose or take other precautions. It is especially important for your healthcare professional to know if you are taking any of the medicines listed below while receiving this medicine. The following interactions have been highlighted for their potential importance, but this list may not include all possible interactions.

Using this medicine with any of the following medicines is not recommended. Your doctor may choose not to treat you with this medication or change some of your other medicines.

• Bromopride
• Potassium Citrate

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating food or certain types of food due to possible interactions. Drinking alcohol or using tobacco with some medicines can also cause interactions. Talk to your healthcare professional about using this medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical conditions may affect how you can use this medicine. Make sure to inform your doctor if you have any other medical issues, especially:

• Dehydration or
• Electrolyte imbalance (high or low levels of minerals in the blood) or
• High fever or
• Severe intestinal infection—these may worsen side effects.

Along with its necessary effects, a medicine may cause some unwanted effects. Although not all of these side effects may happen, if they do occur, they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

• Body spasm, with head and heels bent backward and body bowed forward
• convulsions (seizures)
• depression
• shakiness or tremors
• skin rash
• sore throat or fever
• unusual tiredness
• vomiting (severe or continuing)
• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Drowsiness

Less common

• Blurred vision
• diarrhea
• dizziness
• headache
• muscle cramps

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Arrestin
• Benzacot
• Stemetic
• Ticon
• Tigan
• Tribenzagan

Available Dosage Forms:

• Solution

Therapeutic Class: Antiemetic

Pharmacologic Class: Anticholinergic

Trimethobenzamide is only used to relieve or prevent nausea and vomiting. A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into one of your muscles.

Your doctor may only give you a few doses of this medicine until your condition improves, and then may switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.