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Antihistamines oral liquid (0.625 mg/mL; 0.938 mg/mL; 2.5 mg/5 mL)

Triprolidine

Generic name: triprolidine

Brand names: Histex PD Drops, Histex Syrup, M-Hist PD, PediaClear PD, Histex, Vanaclear PD, Vanahist PD, Zymine, Zymine XR, Tripohist, Histex PDX, Flonase Nighttime Allergy Relief

Used for Fever
Last updated November 3, 2026 0 views
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What is triprolidine?

Triprolidine is an antihistamine that helps relieve sneezing, a runny nose, an itchy nose and throat, and itchy or watery eyes due to allergies like hay fever.

Triprolidine may also be used for other reasons not mentioned in this medication guide.

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How should I take triprolidine?

Use exactly as directed on the label, or as prescribed by your doctor. Cold or cough medicine is only for short-term use until your symptoms go away.

Always follow the directions on the medicine label for giving cough or cold medicine to a child. Do not use the medicine just to make a child sleepy. Misuse of cough or cold medicines in very young children can lead to death.

You must chew the chewable tablet before swallowing it.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

Call your doctor if your symptoms do not improve after 7 days, or if you have a fever, rash, or headaches.

If you need surgery or medical tests, tell the doctor in advance if you have taken this medicine in the past few days.

Store at room temperature away from moisture and heat. Do not let liquid medicine freeze.

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Warnings

Follow all instructions on your medicine label and package. Inform each of your healthcare providers about all your medical conditions, allergies, and all medicines you are taking.

You should not use antihistamines to make a child sleepy.

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Before taking this medicine

You should not use triprolidine if you are allergic to it.

Ask a doctor or pharmacist if triprolidine is safe to use if you have:

  • a breathing disorder such as chronic bronchitis or emphysema;
  • glaucoma; or
  • an enlarged prostate and urination problems.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

This medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU).

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Triprolidine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Triprolidine may cause serious side effects. Stop using triprolidine and call your doctor right away if you have:

  • painful or difficult urination.

Common side effects of triprolidine may include:

  • dizziness, drowsiness;
  • blurred vision;
  • dry mouth, nose, or throat;
  • constipation;
  • increased urination; or
  • feeling nervous or restless (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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What happens if I miss a dose?

Since triprolidine is taken as needed, you might not have a regular dosing schedule. If you miss a dose and it's close to the time for your next dose, just skip the missed dose. Do not take two doses at once.

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What happens if I overdose?

Seek emergency medical help or call the Poison Help line at 1-800-222-1222.

Do not drive or engage in hazardous activities until you understand how triprolidine will affect you. Your reactions may be impaired.

Drinking alcohol can make some side effects of triprolidine worse.

Ask a doctor or pharmacist before using other cough or cold medicines that may have similar ingredients.

Avoid getting too hot or dehydrated during exercise and in hot weather. Triprolidine can reduce sweating, and you may be more likely to suffer from heat stroke.

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What other drugs will affect triprolidine?

Avoid using this medicine with other drugs that make you sleepy or slow your breathing (like opioid medicine, a muscle relaxer, or medicine for anxiety or seizures). Ask a doctor or pharmacist before using any other medication, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed in this medication guide.

This section was rewritten for readability and reviewed for meaning.

Common questions about triprolidine

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Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
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Content is provided for education and is not medical advice. See our medical disclaimer.