Tropicamide and phenylephrine (Ophthalmic)

Tropicamide and phenylephrine combination eye spray is used to dilate (enlarge) the pupil of the eye during certain medical procedures.

This medicine is only to be given by or under the direct supervision of your doctor.

It is very important for your doctor to monitor you or your child's progress closely while using this medicine. This ensures that the medicine is effective and that the infection is completely cleared. Blood tests may be required to check for side effects.

Contact your doctor immediately if you notice any mood or mental changes or unusual behavior, such as confusion about time or place, not recognizing people, hyperactivity, or restlessness.

Get in touch with your doctor right away if you experience blurred vision, changes in vision, or loss of vision. These could be signs of increased pressure in the eye.

This medicine may cause rebound miosis (narrowing of the pupils) the day after receiving it. Discuss this concern with your doctor.

This medicine may cause blurred vision. Do not drive or engage in any activities that could be dangerous until you know how this medicine affects you.

Do not take any other medicines without discussing them with your doctor. This includes both prescription and nonprescription (over-the-counter [OTC]) medicines, as well as herbal or vitamin supplements.

In deciding to use a medicine, you and your doctor need to consider the risks against the benefits. Here are important points to think about:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare professional know if you have other types of allergies, like those to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Current studies have not shown any specific problems in children under 1 year old that would limit the usefulness of tropicamide and phenylephrine combination eye spray. However, this medicine may cause mood or mental changes and issues with lungs, heart, or blood vessels, which may require caution in children.

Geriatric

Current studies have not indicated any specific problems in older adults that would limit the usefulness of tropicamide and phenylephrine combination eye spray.

Interactions with Medicines

Some medicines should never be used together, while in other cases, two different medicines may be used together despite potential interactions. In those situations, your doctor may adjust the dose or take other precautions. It is especially important for your healthcare professional to know if you are taking any of the medicines listed below when you are receiving this medicine. The following interactions are highlighted due to their potential significance but may not be a complete list.

Using this medicine with any of the following medicines is not recommended. Your doctor may choose not to prescribe this medication or may change your other medicines.

• Clorgyline
• Dihydroergotamine
• Iproniazid
• Isocarboxazid
• Linezolid
• Nialamide
• Phenelzine
• Potassium Citrate
• Procarbazine
• Rasagiline
• Selegiline
• Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may adjust the dose or frequency for one or both.

• Amantadine
• Amifampridine
• Buprenorphine
• Bupropion
• Clozapine
• Codeine
• Donepezil
• Ergonovine
• Furazolidone
• Glucagon
• Glycopyrrolate
• Glycopyrronium Tosylate
• Iobenguane I 123
• Iobenguane I 131
• Methacholine
• Methylergonovine
• Midodrine
• Oxycodone
• Pargyline
• Quetiapine
• Revefenacin
• Scopolamine
• Secretin Human
• Tapentadol
• Tiotropium
• Zavegepant

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both drugs may be the best treatment for you. If both are prescribed together, your doctor may alter the dose or frequency for one or both.

• Guanethidine

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken at or around meal times, as certain food interactions may occur. Consuming alcohol or tobacco with some medicines may also lead to interactions. The following interactions are highlighted for their potential significance but may not be a complete list.

Other Medical Problems

Having other medical issues may impact the use of this medicine. Be sure to inform your doctor about any other medical problems, especially:

• Heart or blood vessel disease or
• Hyperthyroidism (overactive thyroid)—Use with caution. May worsen these conditions.

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they may need medical attention.

Check with your doctor or nurse right away if any of the following side effects occur:

Incidence not known

• Blurred vision
• change in color vision
• chest pain or discomfort
• cold, clammy, pale skin
• difficulty seeing at night
• dizziness
• eye discomfort
• increased sensitivity of the eyes to sunlight
• irregular heartbeat
• loss of vision
• mood or mental changes
• muscle stiffness or tightness
• painful irritation of the clear front part of the eye
• slow heart rate
• trouble breathing
• unusual behavior, such as disorientation to time or place, failure to recognize people, hyperactivity, or restlessness
• weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to suggest ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

Incidence not known

• Dry mouth
• headache
• nausea

Other side effects not listed may also happen in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Mydcombi

In Canada

• Phenyltrope

Available Dosage Forms:

• Solution

Therapeutic Class: Mydriatic-Cycloplegic

Pharmacologic Class: Antimuscarinic

Chemical Class: Phenylephrine

A nurse or other trained health professional will give you this medicine in a medical facility. It is given by spraying into your eye. Your doctor will give another spray after 5 minutes.

If you are wearing contact lenses, remove them at least 10 minutes before you receive the eye spray.

Do not use other eye products (eg, artificial tears) within 10 minutes of receiving this medicine.