Tryngolza Autoinjector

Tryngolza Autoinjector is used along with diet to lower triglycerides (a type of fat in the blood) in adults with familial chylomicronemia syndrome (a condition that prevents the body from breaking down fats).

Tryngolza Autoinjector is also used together with diet to reduce triglycerides and lower the risk of swelling of the pancreas (pancreatitis) in adults with severe hypertriglyceridemia (a condition that causes very high triglyceride levels in the blood).

Tryngolza Autoinjector may also be used for purposes not listed in this medication guide.

Use only as directed. Inform your doctor if you are taking other medicines, have other medical conditions, or have allergies.

You should not use Tryngolza Autoinjector if you are allergic to it or any of its ingredients.

It is not known if Tryngolza Autoinjector will harm an unborn baby. Tell your doctor if you are pregnant or planning to become pregnant.

Ask a doctor if it is safe to breastfeed while using Tryngolza Autoinjector.

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Tryngolza Autoinjector may cause serious side effects. Call your doctor right away if you have:

• liver problems--loss of appetite, nausea, vomiting, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of Tryngolza Autoinjector may include:

• pain, bruising, swelling, or irritation where the medicine was injected;
• abnormal liver function tests;
• low levels of platelets in your blood; or
• joint pain or stiffness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Tryngolza Autoinjector is injected under the skin, usually once a month. A healthcare provider may give you this injection or may teach you or your caregiver how to properly use this medicine by yourself.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand how to use an injection.

Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors or has particles in it.

Do not inject within 2 inches of your navel (belly button) or into areas where the skin is hard, tender, red, bruised, scarred, or damaged.

Throw away the autoinjector after one use, even if there is still medicine left inside. Do not reuse the autoinjector. Place them in a puncture-proof "sharps" container and dispose of it following state or local laws. Keep out of the reach of children and pets.

You may need to follow a special diet. Follow your doctor's instructions very carefully.

You may need blood tests to check your liver function before and during treatment with Tryngolza Autoinjector.

Store this medicine in the original carton in the refrigerator. Protect from light.

Take the medicine out of the refrigerator and let it reach room temperature for 30 minutes before using.

Do not warm the medicine with hot water, sunlight, or a microwave.

You may store this medicine at room temperature in the original carton for up to 6 weeks. Throw away any medicine kept at room temperature if it is not used within 6 weeks. Protect from heat.

Use the medicine as soon as you remember. Take your next dose one month after your last dose, and then return to your regular monthly schedule. Do not use two doses at one time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions regarding any restrictions on food, drinks, or activities.

Other drugs may affect Tryngolza Autoinjector, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.