Tylenol PM

Acetaminophen is a medicine that relieves pain and reduces fever. Diphenhydramine is a medicine that helps with allergies.

Tylenol PM is a combination medicine that helps with occasional sleeplessness related to minor aches and pains. Tylenol PM is not for treating sleeplessness when there is no pain, or for sleep issues that happen often.

Tylenol PM is also used to relieve minor aches and pains such as headache, back pain, joint or muscle pain, tooth pain, or menstrual cramps.

Tylenol PM can also help with runny nose, sneezing, itchy nose and throat, and pain or fever caused by allergies, the common cold, or the flu.

Tylenol PM may also be used for other reasons not mentioned in this medication guide.

Use exactly as directed on the label, or as prescribed by your doctor. Tylenol PM is only for short-term use until your symptoms improve.

Do not take more of Tylenol PM than is recommended. An overdose of acetaminophen can harm your liver or cause death. Taking too much diphenhydramine can lead to serious heart issues, seizures, coma, or death.

Tylenol PM is not for use in anyone younger than 12 years old. Do not use this medicine to make a child sleepy. Death can occur from the misuse of antihistamines in very young children.

Do not use this medicine for longer than 2 weeks to treat sleep issues, or longer than 7 days to treat cold or allergy symptoms.

Call your doctor if you still have a fever after 3 days, or if you still have pain after 10 days (or 5 days if you are 12-17 years old). Also call your doctor if your symptoms worsen, or if you have any redness or swelling.

If you need surgery or medical tests, tell the doctor ahead of time if you have taken this medicine in the past few days.

Store at room temperature away from moisture and heat.

Use Tylenol PM exactly as directed. Taking too much acetaminophen can harm your liver or lead to death. Taking too much diphenhydramine can result in serious heart issues, seizures, coma, or death.

Do not use this medicine to make a child sleepy. This medicine is not for anyone younger than 12 years old.

Check with a doctor or pharmacist before using any other medicine that might contain acetaminophen or diphenhydramine. Taking too much of either can result in a fatal overdose.

Drinking alcohol may raise your risk of liver damage while using acetaminophen.

Stop using this medicine and call your doctor immediately if you notice skin redness or a rash that spreads and causes blistering and peeling.

Ask a doctor before taking medicine that contains acetaminophen if you have ever had liver disease or if you drink more than 3 alcoholic beverages per day.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

• liver disease;
• an enlarged prostate or urination problems;
• asthma, chronic obstructive pulmonary disease (COPD), emphysema, or other breathing disorder;
• glaucoma; or
• a condition for which you take warfarin (Coumadin, Jantoven).

Ask a doctor before using this medicine if you are pregnant or breastfeeding. Diphenhydramine may slow breast milk production.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This can happen even if you have taken acetaminophen before without any reaction. Stop taking this medicine and call your doctor immediately if you have skin redness or a rash that spreads and causes blistering and peeling. If you experience this type of reaction, you should never take any medicine that contains acetaminophen again.

The medicine may cause serious side effects. Stop using the medicine and call your doctor right away if you have:

• severe drowsiness;
• painful or difficult urination; or
• liver problems—loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of Tylenol PM may include:

• drowsiness;
• constipation;
• decreased urination;
• dry eyes, blurred vision; or
• dry mouth, nose, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Since Tylenol PM is taken as needed, you might not have a regular dosing schedule. If you miss a dose and it's nearly time for your next dose, just skip the missed dose. Do not take two doses at the same time.

Seek emergency medical help or call the Poison Help line at 1-800-222-1222. Taking too much can be deadly or harm your liver.

Signs of an overdose may include loss of appetite, vomiting, weakness, confusion, ringing in your ears, pain in the upper stomach, dark urine, not urinating, very dry eyes and mouth, yellowing of your skin or eyes, dilated pupils, fast heartbeats, trembling, agitation, hallucinations, or seizures.

Do not drive or do anything dangerous until you know how Tylenol PM will affect you. Your reactions might be affected.

Ask a doctor or pharmacist before using any other medicine that may contain acetaminophen or diphenhydramine. This includes medications for pain, fever, swelling, cold/flu symptoms, or anti-itch creams. Taking too much acetaminophen or diphenhydramine can cause a deadly overdose.

Drinking alcohol may raise your chances of liver damage while taking acetaminophen.

Ask a doctor or pharmacist before using Tylenol PM with any other medicines, especially those that can cause drowsiness (like opioid medication, sleep medicine, a muscle relaxer, or medicine for anxiety or seizures). Inform your doctor about all the medicines you are currently taking and any medicines you begin or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.