Uzedy (injection)

Risperidone injection is used in adults to treat schizophrenia.

Risperdal Consta is used in adults either by itself or with lithium or valproate to treat bipolar disorder.

Risperidone may also be used for reasons not mentioned in this medication guide.

Risperidone is not approved for use in older adults with dementia-related psychosis.

You should not use this medication if you are allergic to risperidone or paliperidone.

Risperidone may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Tell your doctor if you have or have ever had:

• heart disease or a heart attack;
• dizziness, rapid heartbeats, fainting;
• a stroke, a TIA or "mini-stroke";
• Parkinson's disease or a type of dementia called Lewy body dementia;
• trouble swallowing;
• low white blood cell (WBC) counts;
• a severe nervous system reaction while using medicine to treat anxiety, mood disorders, or mental illness such as schizophrenia;
• diabetes (in you or a family member);
• high cholesterol or triglycerides;
• uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
• a seizure;
• low bone mineral density;
• breast cancer;
• dehydration; or
• liver or kidney disease.

Using antipsychotic medicine in the last 3 months of pregnancy may cause serious problems in the newborn. Tell your doctor right away if you get pregnant. Do not stop the medicine without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of risperidone on the baby.

It may be harder for you to get pregnant while you are using this medicine.

If you are breastfeeding, tell your doctor if you notice drowsiness, irregular growth, tremors, and abnormal muscle movements in the nursing baby.

Get emergency medical help if you notice signs of an allergic reaction: hives, trouble breathing, swelling of your face, lips, tongue, or throat.

Using high doses or using risperidone for a long time can lead to a serious movement disorder that may not be reversible. The longer you take risperidone, the higher the chance of developing this disorder, especially if you are a woman or an older adult.

Uzedy can cause serious side effects. Contact your doctor immediately if you experience:

• uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
• breast swelling and tenderness, nipple discharge, loss of interest in sex, impotence, erectile dysfunction, difficulty having an orgasm, missed menstrual periods;
• feeling unusually hot or cold;
• low blood pressure, rapid or strong heartbeats, fluttering in your chest;
• shortness of breath, sudden dizziness (feeling faint);
• seizures;
• trouble swallowing;
• signs of infection—fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding;
• severe nervous system reaction—very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling faint;
• high blood sugar—thirst, frequent urination, dry mouth, fruity breath odor;
• low blood cell counts—fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or
• a painful or prolonged erection.

Common side effects of Uzedy may include:

• headache;
• blurred vision, rash;
• dizziness, drowsiness, feeling tired;
• tremors, twitching or uncontrollable muscle movements, numbness;
• depressed mood, agitation, anxiety, feeling restless;
• back pain, muscle or joint pain, pain in your arms or legs;
• upset stomach, constipation, dry mouth;
• upper stomach pain, nausea, vomiting, diarrhea;
• increased salivation;
• cold symptoms like stuffy nose, sneezing, sore throat;
• increased appetite, weight gain; or
• itching, bruising, swelling, irritation, warmth, redness, and a hard lump (induration) where the injection was given.

This is not a complete list of side effects, and others may occur. Contact your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

If you already use other antipsychotic medication, you may need to keep using it for a short time. Do not change your dose or dosing schedule without your doctor's advice.

You may need to take risperidone by mouth (in pill or liquid form) before you start receiving risperidone injections. Follow your doctor's dosing instructions very carefully.

Risperidone is injected under the skin or into a muscle.

A healthcare provider will give you this injection.

Risperdal Consta is usually given once every 2 weeks. Perseris is usually given once every month. Uzedy is usually given once every month or once every 2 months.

Your blood may need to be tested often.

Your doctor will need to check your progress on a regular basis and you may need other medical tests.

Call your doctor for instructions if you miss an appointment for your risperidone (injection).

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Do not drink alcohol. Dangerous side effects could occur.

Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Avoid driving or hazardous activity until you know how this medicine will affect you. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Using risperidone with other medications that cause drowsiness can make you feel even more tired. Talk to your doctor before taking opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Sometimes, it is not safe to take certain medications together. Some drugs can change the levels of other drugs in your blood, which may increase side effects or make the medicines work less effectively.

Inform your doctor about all the medicines you are currently taking. Many drugs can affect risperidone, especially:

• methylphenidate;
• clozapine; or
• blood pressure medications.

This list is not complete, and many other medications may affect risperidone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.