Valproic acid

Valproic acid is used to treat different kinds of seizure disorders. Valproic acid is sometimes used along with other seizure medications.

Valproic acid is also used to treat manic episodes related to bipolar disorder (manic depression) and to prevent migraine headaches.

Valproic acid may also be used for reasons not mentioned in this medication guide.

Follow all instructions on your prescription label and read all medication guides or instruction sheets. Your doctor may change your dose from time to time. Use the medicine exactly as directed.

Valproic acid oral is taken by mouth. Valproic acid injection is given as an infusion into a vein. A healthcare provider will administer this injection if you cannot take the medicine by mouth.

Drink plenty of water while taking this medication. Your dose may need to be adjusted if you do not get enough fluids each day.

Take this medicine with food if it upsets your stomach.

Measure liquid medicine with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Swallow the capsule whole and do not crush, chew, break, or open it.

Tell your doctor if you see a capsule shell in your stool that was not absorbed or melted in your body. Your blood levels of valproic acid may need to be checked.

You may need to have blood tests often.

If you need surgery, inform the surgeon ahead of time that you are using valproic acid.

In case of emergency, wear or carry medical identification to let others know you use valproic acid.

Do not stop using valproic acid suddenly, even if you feel fine. Stopping suddenly may lead to a serious, life-threatening type of seizure. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture and heat.

Valproic acid can lead to liver failure that may be fatal, especially in children under age 2 and in people with liver issues due to certain genetic disorders.

You should not use valproic acid if you have liver disease, a urea cycle disorder, or a genetic disorder like Alpers' disease or Alpers-Huttenlocher syndrome.

Do not start or stop taking this medicine during pregnancy without your doctor's advice. This medicine may harm an unborn baby or cause birth defects, but having a seizure during pregnancy could harm both the mother and baby.

Do not use valproic acid to prevent migraine headaches if you are pregnant.

Call your doctor right away if the person taking this medicine shows signs of liver or pancreas problems, such as: loss of appetite, upper stomach pain (that may spread to the back), ongoing nausea or vomiting, dark urine, swelling in the face, or jaundice (yellowing of the skin or eyes).

Do not stop using valproic acid without your doctor's advice. Stopping suddenly may lead to a serious, life-threatening type of seizure.

You should not use valproic acid if you are allergic to it, or if you have:

• liver disease;
• a urea cycle disorder; or
• a genetic mitochondrial (MYE-toe-KON-dree-al) disorder such as Alpers' disease or Alpers-Huttenlocher syndrome, especially in a child younger than 2 years old.

Valproic acid can cause liver failure that may be fatal, especially in children under age 2 and in people with liver problems caused by a genetic mitochondrial disorder.

Tell your doctor if you have ever had:

• liver problems caused by a genetic mitochondrial disorder;
• depression, mental illness, or suicidal thoughts or actions;
• a family history of a urea cycle disorder or infant deaths with unknown cause; or
• HIV or CMV (cytomegalovirus) infection.

Some young people have thoughts about suicide when first taking valproic acid. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Using valproic acid during pregnancy may increase the risk of serious birth defects that can develop early in pregnancy, even before you know you are pregnant. Using valproic acid during pregnancy can also affect cognitive ability (reasoning, intelligence, problem-solving) later in your child's life. However, having a seizure during pregnancy could harm both the mother and the baby.

If you take valproic acid for seizures or manic episodes: The benefit of preventing these conditions may outweigh any risks posed by this medicine. There may be other medications that are safer to use during pregnancy. Do not start or stop taking valproic acid without your doctor's advice.

Do not use valproic acid to prevent migraine headaches if you are pregnant or you could become pregnant.

If you are not pregnant, use effective birth control to prevent pregnancy while using valproic acid. Tell your doctor if you start or stop using hormonal contraception that contains estrogen (birth control pills, injections, implants, skin patches, and vaginal rings). Estrogen can interact with valproic acid and make it less effective in preventing seizures.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Get emergency medical help if you notice signs of an allergic reaction (hives, trouble breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you experience a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Call your doctor right away if the person taking valproic acid shows signs of liver or pancreas problems, such as: loss of appetite, upper stomach pain (that may spread to your back), ongoing nausea or vomiting, dark urine, swelling in the face, or jaundice (yellowing of the skin or eyes).

Report any new or worsening symptoms to your doctor, such as: changes in mood or behavior, depression, anxiety, panic attacks, trouble sleeping, or feelings of being impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), or having thoughts about suicide or self-harm.

Call your doctor right away if you have any of these other side effects:

• confusion, tiredness, cold feeling, vomiting, change in your mental state;
• easy bruising, unusual bleeding (nose, mouth, or gums), purple or red pinpoint spots under your skin;
• severe drowsiness; or
• worsening seizures.

Severe drowsiness may be more likely in older adults.

Common side effects of valproic acid may include:

• nausea, vomiting, stomach pain, diarrhea;
• dizziness, drowsiness, weakness;
• headache;
• tremors, problems with walking or coordination;
• blurred vision, double vision;
• hair loss; or
• changes in appetite, weight gain.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Take the medicine as soon as you can, but skip the missed dose if it is nearly time for your next dose. Do not take two doses at the same time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

• Drinking alcohol may increase certain side effects of valproic acid.

• Avoid driving or hazardous activity until you know how valproic acid will affect you. Your reactions could be impaired.

Sometimes it is not safe to use certain medications together. Some drugs can change the levels of other drugs in your blood, which may increase side effects or make the medications work less effectively.

Many drugs can affect valproic acid. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.