On this page · 9 sections

Valu-Dryl

Generic name: diphenhydramine

Brand names: Allergy (Diphenhydramine HCl), Allergy Relief (Diphenhydramine HCl), Banophen, Benadryl, Benadryl Allergy, Benadryl Children's Allergy, Benadryl Children's Allergy Fastmelt, Benadryl Children's Dye Free, Benadryl DF, Benadryl Dye Free Allergy, Benadryl Fastmelt, Benadryl Ultratab, Children's Allergy, Children's Allergy Relief, Childrens Dye-Free Allergy Relief, Compoz Nighttime Sleep Aid, Diphedryl, Diphenhist, Dormin, Geri-Dryl

Last updated November 3, 2026 0 views
Share

What is Valu-Dryl?

Valu-Dryl is an antihistamine that helps relieve sneezing, a runny nose, watery eyes, hives, skin rash, itching, and other symptoms of colds or allergies.

Valu-Dryl is also used to help with motion sickness, to promote sleep, and to treat some symptoms of Parkinson's disease. This sleep aid is not for use in children younger than 12 years old.

There are many brands and forms of diphenhydramine available. Not all brands are mentioned in this leaflet.

Valu-Dryl may also be used for reasons not listed in this medication guide.

This section was rewritten for readability and reviewed for meaning.

How should I take Valu-Dryl?

Use exactly as directed on the label or as your doctor prescribes. Valu-Dryl is meant for short-term use until your symptoms improve.

Taking too much Valu-Dryl can cause serious heart issues, seizures, coma, or death.

Always follow the instructions on the medicine label for giving Valu-Dryl to a child. Do not use this medicine just to make a child sleepy. Misusing antihistamines in very young children can lead to death.

For motion sickness, take Valu-Dryl 30 minutes before you expect to be in a situation that may cause motion sickness (like a long car ride, flying, boating, amusement park rides, etc.). Continue taking this medicine with meals and at bedtime while you are in a motion-sickness situation.

As a sleep aid, take Valu-Dryl within 30 minutes before bedtime.

You must chew the chewable tablet before swallowing it.

Measure liquid medicine carefully. Use the dosing syringe provided, or a medicine dose-measuring device (not a kitchen spoon).

Remove an orally disintegrating tablet from the package only when you are ready to take it. Place the tablet in your mouth and let it dissolve without chewing. Swallow several times as it dissolves.

Contact your doctor if the condition you are treating with Valu-Dryl does not improve, or if you have a fever along with a headache, cough, or skin rash.

Do not use Valu-Dryl for more than 2 weeks to treat sleep problems, or for longer than 7 days to treat cold or allergy symptoms.

Valu-Dryl can affect the results of allergy skin tests. Inform any doctor who treats you that you are using Valu-Dryl.

Store at room temperature away from moisture and heat.

This section was rewritten for readability and reviewed for meaning.

Warnings

Use Valu-Dryl exactly as directed. Taking too much Valu-Dryl can cause serious heart problems, seizures, coma, or death.

Do not use this medicine to make a child sleepy. Valu-Dryl sleep aid medicine is not for children younger than 12 years old.

This section was rewritten for readability and reviewed for meaning.

Before taking this medicine

You should not use Valu-Dryl if you are allergic to it.

Ask a doctor or pharmacist if this medicine is safe for you if you have ever had:

  • an enlarged prostate or problems with urination;
  • asthma, chronic obstructive pulmonary disease (COPD), or another breathing issue;
  • glaucoma; or
  • a thyroid disorder.

Ask a doctor before using this medicine if you are pregnant or breastfeeding. Valu-Dryl may slow down breast milk production.

This section was rewritten for readability and reviewed for meaning.

Valu-Dryl side effects

Get emergency medical help if you notice signs of an allergic reaction: hives; trouble breathing; swelling of your face, lips, tongue, or throat.

Valu-Dryl may cause serious side effects. Stop using Valu-Dryl and call your doctor right away if you experience:

  • severe drowsiness; or
  • painful or difficult urination.

Older adults may be more likely to experience side effects such as dry mouth, constipation, and confusion.

Common side effects of Valu-Dryl may include:

  • drowsiness;
  • dry eyes, blurred vision;
  • dry mouth, nose, or throat;
  • decreased urination;
  • constipation;
  • feeling restless or excited (especially in children); or
  • daytime drowsiness or a "hangover" feeling after using it at night.

This is not a complete list of side effects, and other side effects may happen. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

This section was rewritten for readability and reviewed for meaning.

What happens if I miss a dose?

Since Valu-Dryl is taken as needed, you might not follow a specific dosing schedule. If you miss a dose and it's nearly time for your next dose, just skip the missed dose. Do not take two doses at once.

This section was rewritten for readability and reviewed for meaning.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of diphenhydramine can be fatal.

Overdose symptoms may include vomiting, confusion, severe drowsiness, ringing in your ears, no urination, very dry eyes and mouth, dilated pupils, fast heartbeats, tremor, agitation, hallucinations, or seizure.

Avoid driving or dangerous activities until you know how Valu-Dryl will affect you. Your reactions could be impaired.

Drinking alcohol can increase certain side effects of diphenhydramine.

Ask a doctor or pharmacist before using any other medicine that may contain Valu-Dryl. This includes medicines for sleep, cold/allergy symptoms, or anti-itch medicine used on the skin. Using too much of this medicine may lead to a fatal overdose.

This section was rewritten for readability and reviewed for meaning.

What other drugs will affect Valu-Dryl?

Ask a doctor or pharmacist before using Valu-Dryl with any other medicines, especially those that can cause drowsiness (like opioid medication, sleep medicine, a muscle relaxer, or medicines for anxiety or seizures). Inform your doctor about all the medicines you are currently taking and any that you begin or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

This section was rewritten for readability and reviewed for meaning.

Common questions about Valu-Dryl

What are the strongest sleeping pills?
There are many different types of sleeping pills available. Some require a prescription, while others are available over the counter. In general, prescription sleeping pills are stronger than those found over the counter. Some strong sleeping pill names include zolpidem, temazepam, and suvorexant. Continue reading
What is the max dose of diphenhydramine for adults?
The maximum oral dose of diphenhydramine for adults is generally reported as 50 to 100 mg for a single dose or no more than 300 mg in 24 hours, but this can vary depending on what condition diphenhydramine is being used for, the salt of diphenhydramine used (there are two salts available in the US diphenhydramine citrate and diphenhydramine chloride), the age of the person, how much diphenhydramine they have tolerated before, and if they are on any interacting medications. Taking too much diphenhydramine can be fatal. Continue reading
How Fast Does Benadryl Work? Onset Time and Duration
Benadryl starts working within 30 minutes after taking it orally, with peak effects reached in 1-2 hours. The antihistamine effects last 4-6 hours for most people. Injectable Benadryl works even faster than oral tablets, providing quicker relief for severe allergic reactions. Continue reading
Does diphenhydramine raise blood pressure?
Increased blood pressure is not a typical side effect of diphenhydramine, a first-generation antihistamine that lowers the effects of histamines in your body. However, in rare cases, the drug may cause hypotension, or decreased blood pressure. This side effect is most likely to occur in people who are over the age of 60. Continue reading
Can diphenhydramine be used as a sleep aid?
Diphenhydramine can be used as a short-term sleep aid to help ease occasional sleep problems, such as when you have a cold or cough and it is preventing you from falling asleep. Older adults, children under age 16 and pregnant women should avoid taking diphenhydramine, as the risks to these groups may outweigh the benefits. Continue reading
Does Benadryl help with or cause anxiety?
No, Benadryl does not treat anxiety, and in some people it can cause it. Benadryl (diphenhydramine) is an allergy medicine that often makes people sleepy, so it may feel calming for a few hours. But drowsiness is not the same as treating anxiety, and Benadryl is not FDA-approved for anxiety. Continue reading
Does Mucinex help with Covid?
Mucinex does not prevent or cure COVID‑19, but it can help some people feel better by easing symptoms like chest congestion and cough. It should be used only for symptom relief and never as a substitute for COVID‑19–specific treatments, such as antivirals prescribed by your doctor. Continue reading
Which antihistamines make you drowsy?
First-generation antihistamines, like Benadryl (diphenhydramine) and Chlor-Trimeton (chlorpheniramine), often cause sedation. This can include drowsiness, fatigue, and reduced alertness or concentration. Continue reading
Diphenhydramine Hydrochloride vs Citrate: What's the difference?
The difference between diphenhydramine hydrochloride and diphenhydramine citrate is that the salt used to bind the diphenhydramine, is different. For diphenhydramine hydrochloride the salt is hydrochloride and for diphenhydramine citrate the salt is citrate. This salt can change how quickly and effectively the diphenhydramine dissolves and is absorbed but once it is in the body it has no effect. Essentially 25 mg of diphenhydramine hydrochloride is equivalent to 38 mg of diphenhydramine citrate. Continue reading

Related medicines

Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
General medicine information Consumer-friendly language

Content is provided for education and is not medical advice. See our medical disclaimer.