Vepdegestrant

Vepdegestrant is used in adults to treat a specific type of breast cancer that is advanced or has spread to other parts of the body (metastatic) and has gotten worse after at least one hormone therapy.

Your doctor will confirm that you have the right tumor type to be treated with vepdegestrant.

Vepdegestrant may also be used for reasons not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not change your dose or stop taking this medicine without your doctor's advice.

Vepdegestrant is usually taken once per day with food. Follow your doctor's instructions.

Swallow the tablet whole and do not split, crush, chew, or dissolve it. Do not take a tablet that is broken, cracked, or damaged.

If you vomit shortly after taking vepdegestrant, do not take another dose. Take your next dose as scheduled.

Your heart function and blood will need to be tested before and during treatment. Your treatment may be changed based on the results.

Store at room temperature away from moisture and heat.

Use only as directed. Inform your doctor if you take other medicines or have other medical conditions or allergies.

Tell your doctor if you have or have ever had:

• heart failure;
• heart rhythm disorder such as long QT syndrome; or
• an electrolyte imbalance (such as low blood levels of potassium or magnesium).

Vepdegestrant can harm an unborn baby if the mother or the father is using vepdegestrant.

• If you are a woman, you may need to have a pregnancy test before starting this treatment. Use birth control while using this medicine and for at least 2 weeks after your last dose.
• If you are a man, use birth control if your sex partner is able to get pregnant. Keep using birth control for at least 2 weeks after your last dose.
• Tell your doctor right away if you become pregnant or think you may be pregnant.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

Vepdegestrant may affect fertility in men or women. Pregnancy could be harder to achieve while either parent is using this medicine.

Get emergency medical help if you have signs of an allergic reaction: hives, difficulty breathing, swelling of your face, lips, tongue, or throat.

Vepdegestrant can affect your heart rhythm. Call your doctor right away if you have signs of an abnormal heart rhythm, including feeling lightheaded or faint, dizziness, a pounding or fast heartbeat, shortness of breath, or chest pain.

Vepdegestrant may cause serious side effects. Call your doctor at once if you have:

• signs of an electrolyte imbalance--increased thirst or urination, constipation, muscle weakness, leg cramps, numbness or tingling, feeling jittery, fluttering in your chest.

Your cancer treatments may be delayed, reduced, or permanently discontinued if you have certain side effects.

Common side effects of vepdegestrant may include:

• abnormal blood tests;
• abnormal electrocardiogram or ECG;
• bone or muscle pain;
• tiredness;
• nausea, constipation; or
• loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Skip the missed dose and take your next dose at the usual time. Do not take two doses on the same day.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Avoid taking an herbal supplement that contains St. John's wort.

Grapefruit may interact with vepdegestrant and cause side effects. Avoid consuming grapefruit products.

Sometimes, using certain medicines together can be unsafe. Some drugs can change the levels of other drugs in your blood, which may increase side effects or make the medicines work less well.

Vepdegestrant can cause a serious heart problem. Your risk may be higher if you also take certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Other drugs may affect vepdegestrant, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you are using.