Vilazodone

Vilazodone is an antidepressant that is used to treat major depressive disorder (MDD).

Vilazodone may also be used for reasons not mentioned in this medication guide.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take with food.

Your symptoms may not improve for up to several weeks.

Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated.

Do not stop using vilazodone suddenly, or you could have unpleasant symptoms (such as agitation, confusion, tingling or electric shock feelings). Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat.

Some young people have thoughts about suicide when they first start taking an antidepressant. Be aware of any changes in your mood or symptoms. Tell your doctor about any new or worsening symptoms.

Vilazodone is not approved for use by anyone younger than 18 years old.

Do not stop using vilazodone without first consulting your doctor.

Do not use vilazodone if you have taken an MAO inhibitor in the last 14 days. This could lead to a dangerous drug interaction. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

After you stop taking vilazodone, you must wait at least 14 days before beginning an MAOI.

Let your doctor know if you are taking stimulant medicine, opioid medicine, herbal products, or any medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or to prevent nausea and vomiting. An interaction with vilazodone could lead to a serious condition called serotonin syndrome.

Inform your doctor if you have ever had:

• liver or kidney disease;
• a bleeding or blood clotting disorder;
• narrow-angle glaucoma;
• seizures or epilepsy;
• bipolar disorder (manic depression);
• sexual problems;
• drug addiction or suicidal thoughts; or
• if you drink alcohol.

Some young people may have thoughts of suicide when they first start taking an antidepressant. Your doctor should monitor your progress during regular visits. Your family or other caregivers should also watch for changes in your mood or symptoms.

Taking vilazodone during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop vilazodone without consulting your doctor.

If you are pregnant, your name may be included in a pregnancy registry to track the effects of vilazodone on the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

Not approved for use by anyone younger than 18 years old.

Get emergency medical help if you have signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Vilazodone may cause serious side effects. Call your doctor at once if you have:

• a seizure (convulsions);
• blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
• easy bruising, unusual bleeding;
• racing thoughts, unusual risk-taking behavior, decreased inhibitions, feelings of extreme happiness or sadness; or
• low levels of sodium in the body--headache, confusion, slurred speech, severe weakness, loss of coordination, feeling unsteady.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects of vilazodone may include:

• nausea, vomiting;
• diarrhea; or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Usual Adult Dose for Depression:

Initial dose: 10 mg orally once a day for 7 days, followed by 20 mg orally once a day for an additional 7 daysMaintenance dose: 40 mg orally once a dayComment: This drug should be taken with food.Use: Treatment of major depressive disorder (MDD)

Take the medicine as soon as you remember, but skip the missed dose if it's nearly time for your next dose. Do not take two doses at once.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of vilazodone can be fatal.

Drinking alcohol with vilazodone can cause side effects.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with vilazodone may cause you to bruise or bleed easily.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Using vilazodone with other drugs that cause drowsiness can make you feel more tired. Talk to your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all the medicines you are currently taking. Many drugs can affect vilazodone, especially:

• any other antidepressants;
• mephenytoin;
• St. John's wort;
• tramadol;
• a diuretic or "water pill";
• medicine to treat anxiety, mood disorders, or mental illness such as schizophrenia;
• a blood thinner--warfarin, Coumadin, Jantoven; or
• migraine headache medicine--sumatriptan, Imitrex, Maxalt, Treximet, and others.

This list is not complete, and many other drugs may affect vilazodone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

• What are some common side effects of antidepressants?