Yonsa (Oral)

Note: Females of childbearing capacity ought to not make use of or deal with abiraterone tablets without defense (eg, gloves).

Abiraterone is used in combination with methylprednisolone to deal with individuals with metastatic castration-resistant prostate cancer (prostate cancer that is resistant to medical or surgical treatments that lower testosterone and has actually currently infected other parts of the body).

This medicine is offered only with your doctor's prescription.

It is very crucial that your doctor check your progress at regular brows through to make sure that this medication is working effectively. Blood and urine examinations will certainly be required to check for any unwanted effects that may be caused by this medication.

Women and kids ought to not utilize this medicine. Expecting ladies or ladies that might conceive should not manage or touch the tablet computers without security (eg, gloves). This medicine may likewise create abnormality if the father is utilizing it when his sexual companion conceives. You should utilize a prophylactic and one more effective approach of birth control throughout treatment with this medication and for at the very least 3 weeks after the last dosage. If a pregnancy happens while you are using this medicine, inform your physician immediately.

If you plan to have children, talk with your medical professional before using this medicine. Some males using this medicine have ended up being infertile (incapable to have children).

You will likewise need to have your blood pressure determined prior to beginning this medicine and while you are utilizing it. If you see any adjustments to your suggested high blood pressure, call your doctor today. If you have inquiries concerning this, speak with your doctor.

Do not disrupt or quit using this medication along with methylprednisolone without very first asking your medical professional. This might raise your danger of having adrenal gland troubles. Talk with your medical professional if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, psychological depression, queasiness, skin rash, uncommon fatigue or weakness, or throwing up.

Consult your medical professional right away if you have discomfort or inflammation in the upper tummy, light stools, dark urine, anorexia nervosa, queasiness, uncommon fatigue or weakness, or yellow eyes or skin. These might be signs of a severe liver problem.

This medication together with methylprednisolone might enhance your threat for cracks when utilized with a radiation therapy (eg, radium Ra 223 dichloride). Talk with your physician about this threat.

Do not take various other medications unless they have been gone over with your physician. This consists of prescription or nonprescription (over the counter [OTC] medicines and herbal or vitamin supplements.

In deciding to utilize a medication, the risks of taking the medication needs to be considered against the good it will do. This is a choice you and your doctor will certainly make. For this medicine, the adhering to need to be taken into consideration:

Allergies

Inform your medical professional if you have ever had any type of uncommon or allergic reaction to this medication or any various other medicines. Also inform your healthcare specialist if you have any various other types of allergies, such as to foods, dyes, chemicals, or animals. For non-prescription items, reviewed the label or package components thoroughly.

Pediatric

Abiraterone is not shown for usage in the pediatric population. Security and efficacy have not been established.

Geriatric

Ideal research studies performed to day have not demonstrated geriatric-specific problems that would certainly restrict the efficiency of abiraterone in the elderly. Nevertheless, senior individuals are a lot more conscious the results of this medicine than more youthful adults.

Breast Feeding

There are no ample researches in females for determining baby danger when utilizing this medication throughout breastfeeding. Consider the possible advantages versus the prospective risks prior to taking this drug while breastfeeding.

Interactions with Medicines

Although specific medicines must not be used together in any way, in other instances 2 various medications may be made use of together even if a communication might occur. In these instances, your medical professional may intend to transform the dosage, or various other safety measures may be required. When you are taking this medicine, it is specifically crucial that your health care expert understand if you are taking any of the medications listed here. The complying with communications have actually been selected on the basis of their prospective relevance and are not always all-inclusive.

Using this medicine with any of the following medications is not recommended. Your medical professional may choose not to treat you with this drug or change a few of the various other medicines you take.

• Daprodustat
• Dasabuvir
• Eliglustat
• Selexipag

Utilizing this medicine with any of the adhering to medications is generally not suggested, but may be needed in some cases. If both medications are recommended together, your physician might change the dose or just how frequently you use one or both of the medicines.

• Abametapir
• Acarbose
• Albiglutide
• Alogliptin
• Amiodarone
• Amphetamine
• Apalutamide
• Aripiprazole
• Atomoxetine
• Benzphetamine
• Canagliflozin
• Carbamazepine
• Carvedilol
• Cerivastatin
• Chlorpropamide
• Cilostazol
• Clomipramine
• Clozapine
• Codeine
• Dabrafenib
• Dapagliflozin
• Desipramine
• Desloratadine
• Deutetrabenazine
• Dextroamphetamine
• Dihydrocodeine
• Domperidone
• Donepezil
• Doxepin
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Dulaglutide
• Duloxetine
• Empagliflozin
• Encainide
• Enclomiphene
• Enzalutamide
• Ertugliflozin
• Exenatide
• Fedratinib
• Fenfluramine
• Fexinidazole
• Flecainide
• Fluoxetine
• Fosphenytoin
• Glimepiride
• Glipizide
• Glyburide
• Haloperidol
• Hydroxyamphetamine
• Ifosfamide
• Iloperidone
• Imipramine
• Insulin
• Insulin Aspart, Recombinant
• Insulin Bovine
• Insulin Degludec
• Insulin Detemir
• Insulin Glulisine
• Insulin Lispro, Recombinant
• Itraconazole
• Ivosidenib
• Linagliptin
• Liraglutide
• Lisdexamfetamine
• Lixisenatide
• Lofexidine
• Loperamide
• Lumacaftor
• Lurasidone
• Mavacamten
• Metformin
• Methamphetamine
• Methoxyphenamine
• Metoprolol
• Mexiletine
• Miglitol
• Mitotane
• Montelukast
• Naloxegol
• Nateglinide
• Nebivolol
• Nicergoline
• Nortriptyline
• Omaveloxolone
• Ondansetron
• Ospemifene
• Oxycodone
• Ozanimod
• Paclitaxel
• Paroxetine
• Perphenazine
• Phenobarbital
• Phenytoin
• Pimozide
• Pioglitazone
• Piperaquine
• Pitolisant
• Pixantrone
• Prajmaline
• Pramlintide
• Primidone
• Propafenone
• Radium Ra 223 Dichloride
• Rifampin
• Rifapentine
• Risperidone
• Rosiglitazone
• Rosuvastatin
• Saxagliptin
• Semaglutide
• Simeprevir
• Sitagliptin
• St John's Wort
• Tamoxifen
• Tamsulosin
• Thioridazine
• Timolol
• Tolazamide
• Tolbutamide
• Tolperisone
• Tolterodine
• Tramadol
• Trimipramine
• Tropisetron
• Tucatinib
• Venlafaxine
• Vernakalant
• Voglibose
• Vortioxetine
• Yohimbine
• Zuclopenthixol

Utilizing this medicine with any one of the complying with medicines may trigger a raised threat of certain adverse effects, however making use of both drugs may be the very best therapy for you. If both medicines are prescribed with each other, your medical professional may transform the dose or just how typically you use one or both of the medicines.

• Dextromethorphan
• Repaglinide

Interactions with Food/Tobacco/Alcohol

Certain medications ought to not be made use of at or around the time of consuming food or consuming specific types of food considering that interactions might occur. Utilizing alcohol or tobacco with specific medicines might likewise trigger communications to happen. Talk about with your health care expert making use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The visibility of other clinical troubles might impact making use of this medication. Make certain you inform your medical professional if you have any various other medical troubles, particularly:

• Adrenal or pituitary issues, history of or
• Heart attack, current or
• Heart failure or
• Heart or blood vessel condition, history of or
• Heart rhythm problems (eg, ventricular arrhythmia, QT prolongation, torsades de pointes) or
• Hypertension (high blood pressure) or
• Hypokalemia (reduced potassium in the blood)-- Use with care. May make these problems even worse.

• Liver disease, modest-- Use with care. The impacts might be boosted as a result of slower elimination of the medication from the body.

• Liver condition, extreme-- Should not be utilized in individuals with this problem.

Along with its necessary results, a medicine might create some unwanted results. Although not all of these negative effects may take place, if they do happen they might require medical attention.

Contact your doctor quickly if any one of the adhering to negative effects happen:

Extra common

• Bladder pain
• bloody or cloudy pee
• obscured vision
• body pains or pain
• chills
• cough
• decreased pee
• challenging, burning, or painful peeing
• wooziness
• completely dry mouth
• ear congestion
• fainting
• fast, slow, or irregular heartbeat
• fever
• fractures
• regular urge to urinate
• frustration
• enhanced thirst
• anorexia nervosa
• loss of voice
• reduced back or side discomfort
• state of mind changes
• nausea or vomiting or throwing up
• pins and needles or prickling in the hands, feet, or lips
• anxiety
• battering in the ears
• runny or stuffy nose
• seizures
• slow-moving or quick heart beat
• sneezing
• aching throat
• swelling
• trouble breathing
• uncommon blood loss or bruising
• unusual fatigue or weak point

Much less typical

• Chest pain, discomfort, or rigidity
• expanded neck capillaries
• irregular breathing
• weight gain

Occurrence not understood

• Clay-colored stools
• dark pee
• looseness of the bowels
• basic feeling of pain or ailment
• irritation, rash
• muscle mass cramp, convulsion, discomfort, or rigidity
• tummy pain, continuing
• enlarging of bronchial secretions
• undesirable breath odor
• vomiting of blood
• yellow eyes or skin

Some side effects may occur that normally do not need medical focus. These adverse effects might vanish during treatment as your body adjusts to the medication. Additionally, your health care specialist might have the ability to tell you about methods to prevent or decrease some of these negative effects. Talk to your healthcare specialist if any one of the adhering to side effects proceed or are irritating or if you have any type of concerns regarding them:

Extra usual

• Constipation
• drops
• sensation of warmth
• groin pain
• raised urge to urinate during the evening
• joint swelling or discomfort
• soreness of the face, neck, arms, and occasionally, top chest
• trouble sleeping
• waking to pee in the evening

Opposite side effects not detailed may additionally occur in some patients. If you notice any various other results, consult your medical care specialist.

Call your doctor for clinical suggestions concerning negative effects. You might report negative effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Yonsa

Readily Available Dosage Forms:

• Tablet

Healing Class: Antiandrogen

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have questions.

Swallow the tablets whole with water. Do not crush or chew the tablets.

You may take this tablet with or without food.

Use only the brand of this medicine that your doctor prescribed. Different brands have different dosages and effects when taken with food.

Your doctor may give you other medicines (eg, gonadotropin-releasing hormone) unless you had a surgery to lower the amount of testosterone in your body.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):For castration-resistant prostate cancer: Adults—500 milligrams (mg) (four 125 mg tablets taken as a single dose) once a day, taken together with 4 mg methylprednisolone 2 times a day. Children—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If you missed a dose of this medicine, take your normal dose the following day. If more than one daily dose is missed, call your doctor.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

• Why is Yonsa taken with methylprednisolone?
• How long does it take for Yonsa to work?
• Is Yonsa a form of chemotherapy?
• What's the difference between Yonsa and Zytiga?
• Why is prednisone prescribed with Zytiga?
• What does abiraterone therapy do?