Zembrace Symtouch (Subcutaneous)

Sumatriptan injection is made use of to deal with intense migraine headache assaults and collection headaches in adults. Sumatriptan operates in the brain to ease the pain from migraine headache headaches. It belongs to the group of medications called triptans.

Many individuals locate that their frustrations vanish completely after they use sumatriptan. Other individuals locate that their frustrations are a lot less uncomfortable, which they are able to return to their typical tasks despite the fact that their migraines are not entirely gone. Sumatriptan commonly eases other signs that happen along with a migraine headache, such as nausea or vomiting, vomiting, sensitivity to light, and level of sensitivity to sound.

Sumatriptan is not an ordinary painkiller. It will certainly not relieve any kind of pain other than migraine frustrations. This medication is generally used for people whose migraines are not relieved by acetaminophen, pain killers, or other pain relievers.

Sumatriptan has caused severe negative effects in some individuals, especially in those that have heart or blood vessel disease. Be sure that you review with your physician the risks of utilizing this medication as well as its advantages.

This medicine is readily available only with your medical professional's prescription.

It is really essential that your physician inspect your progress at routine gos to. This will allow your physician to see if the medicine is functioning properly and to choose if you must continue to use it and to check for unwanted effects.

Contact your doctor if you have actually used this medicine and have actually not had excellent alleviation. Also, contact your medical professional if your migraine or collection headaches are worse, or if they are occurring more frequently, than prior to you started getting this medication.

You must not get this medicine if you are making use of or have actually used an MAO inhibitor (MAOI) such as phenelzine (Nardil ® )or tranylcypromine (Parnate ® )within the past 2 weeks. Do not use this medicine if you have used other triptan migraine headache medications. Some examples of triptan medicines are almotriptan (Axert ®), eletriptan (Relpax ®), naratriptan (Amerge ®), or zolmitriptan (Zomig ®). Some examples of ergot-type medicines are dihydroergotamine (D.H.E. 45 ®, Migranal ®), ergotamine (Bellergal ®, Cafergot ®, Ergomar ®, Wigraine ® ), or methysergide (Sansert ®)

. Talk to your medical professional if you have actually made use of sumatriptan and your migraine headache became worse or started taking place regularly.

The needle shield of the Imitrex ® prefilled syringe has completely dry all-natural rubber (a derivative of latex), which may create allergies in individuals that are sensitive to latex. Inform your medical professional if you have a latex allergy before getting this medication.

This medication might raise your risk of having heart rhythm troubles, heart attack, angina, or stroke. This is most likely to happen if you or a member of the family already has heart disease, if you have diabetes mellitus, high blood pressure, or if you smoke. Call your medical professional immediately if you have any symptoms of a heart problem, such as chest pain or discomfort, an unequal heartbeat, queasiness or throwing up, discomfort or discomfort in the shoulders, arms, jaw, back, or neck, or sweating. Call your doctor as soon as possible if you have any type of symptoms of a stroke, such as complication, problem with speaking, dual vision, frustrations, a lack of ability to move the arms, legs, or face muscles, a failure to speak, or slow speech.

Consult your medical professional immediately if you have upper body discomfort, jaw or neck tightness after using this medicine. Additionally, tell your medical professional if you have sudden or extreme abdominal or stomach discomfort or bloody looseness of the bowels after utilizing this medicine.

Consult your medical professional right away if obscured vision, trouble in analysis, or any kind of various other modification in vision happens during or after your treatment. Your medical professional may desire you to have your eyes checked by an ophthalmologist (optometrist).

Making use of sumatriptan alone or in combination with other migraine medications for 10 or even more days each month may cause worsening of headache. You might maintain a headache diary to tape the frustration regularity and drug use.

Ensure your doctor learns about all the other medications you are using. Sumatriptan may trigger a major problem called serotonin disorder when used with some medicines. This especially includes medications made use of to deal with clinical depression, such as citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, olanzapine, paroxetine, sertraline, venlafaxine, Celexa ®, Cymbalta ®, Effexor ®, Lexapro ®, Luvox ®, Paxil ®, Prozac ®, Sarafem ®, Symbyax ®, or Zoloft ®. Check with your medical professional right now if you have agitation, complication, looseness of the bowels, excitement while chatting that is not typical, high temperature, overactive reflexes, inadequate coordination, restlessness, shuddering, sweating, shivering or trembling that you can not regulate, or twitching. These can be signs of serotonin syndrome.

This medicine may create serious kinds of allergic reaction, including anaphylaxis and angioedema. These can be dangerous and require immediate clinical interest. One of the most significant signs of this reaction are extremely quick or uneven breathing, wheezing for breath, or fainting. Various other indicators might include adjustments in color of the skin of the face, really fast but uneven heart beat or pulse, hive-like swellings on the skin, and puffiness or swellings of the eyelids or around the eyes. If these impacts occur, obtain emergency situation aid at the same time.

Consuming alcohols can make frustrations worse or cause brand-new headaches to happen. People who struggle with serious migraines ought to avoid liquors, particularly throughout a headache.

This medicine might trigger some people to end up being dizzy, drowsy, or less sharp than they are typically. Do not drive or do anything else that can be dangerous until you understand exactly how this medication affects you.

In making a decision to make use of a medication, the threats of taking the medication needs to be evaluated against the excellent it will certainly do. This is a decision you and your doctor will certainly make. For this medication, the following must be taken into consideration:

Allergies

Inform your medical professional if you have actually ever had any uncommon or allergic reaction to this medication or any type of various other medicines. Additionally tell your health care expert if you have any kind of various other types of allergies, such as to foods, dyes, chemicals, or pets. For non-prescription items, read the label or bundle components thoroughly.

Pediatric

Suitable studies have actually not been performed on the connection old to the results of sumatriptan shot in the pediatric populace. Use of Imitrex ® is not recommended in kids. Safety and efficiency have actually not been established.

Geriatric

Use of sumatriptan injection is not recommended in senior clients with kidney problems, heart or capillary illness, or high blood pressure, and must not be used by elderly patients with liver troubles.

Breast Feeding

There are no sufficient researches in females for identifying infant risk when utilizing this medication during breastfeeding. Evaluate the potential benefits versus the potential risks prior to taking this drug while breastfeeding.

Interactions with Medicines

Although specific medicines need to not be utilized with each other in all, in various other cases 2 different medicines might be used together even if an interaction could happen. In these cases, your physician may wish to transform the dose, or various other preventative measures may be necessary. When you are taking this medicine, it is specifically essential that your health care professional recognize if you are taking any of the medicines listed below. The following interactions have actually been chosen on the basis of their potential relevance and are not always all-encompassing.

Using this medication with any one of the following medicines is not advised. Your doctor might decide not to treat you with this medication or alter some of the other medications you take.

• Almotriptan
• Bromocriptine
• Dihydroergotamine
• Eletriptan
• Ergoloid Mesylates
• Ergonovine
• Ergotamine
• Frovatriptan
• Furazolidone
• Iproniazid
• Isocarboxazid
• Linezolid
• Methylene Blue
• Methylergonovine
• Methysergide
• Moclobemide
• Naratriptan
• Nialamide
• Phenelzine
• Procarbazine
• Rasagiline
• Rizatriptan
• Safinamide
• Selegiline
• Tranylcypromine
• Zolmitriptan

Using this medicine with any of the adhering to medicines is generally not advised, however may be needed sometimes. If both medications are suggested with each other, your doctor might transform the dose or how commonly you utilize one or both of the medicines.

• Alfentanil
• Amineptine
• Amitriptyline
• Amitriptylinoxide
• Amoxapine
• Amphetamine
• Benzhydrocodone
• Benzphetamine
• Buprenorphine
• Bupropion
• Butorphanol
• Citalopram
• Clomipramine
• Codeine
• Desipramine
• Desvenlafaxine
• Dexfenfluramine
• Dextroamphetamine
• Dextromethorphan
• Dibenzepin
• Dihydrocodeine
• Dolasetron
• Doxepin
• Duloxetine
• Escitalopram
• Fenfluramine
• Fentanyl
• Fluoxetine
• Fluvoxamine
• Gepirone
• Granisetron
• Hydrocodone
• Hydromorphone
• Hydroxyamphetamine
• Imipramine
• Lasmiditan
• Levomilnacipran
• Levorphanol
• Lisdexamfetamine
• Lithium
• Lofepramine
• Lorcaserin
• Melitracen
• Meperidine
• Metaxalone
• Methamphetamine
• Milnacipran
• Mirtazapine
• Morphine
• Morphine Sulfate Liposome
• Nalbuphine
• Nefazodone
• Nortriptyline
• Ondansetron
• Opipramol
• Oxycodone
• Oxymorphone
• Palonosetron
• Paroxetine
• Pentazocine
• Protriptyline
• Reboxetine
• Remifentanil
• Sertraline
• Sibutramine
• St John's Wort
• Sufentanil
• Tapentadol
• Tianeptine
• Tramadol
• Trazodone
• Trimipramine
• Venlafaxine
• Vilazodone
• Vortioxetine
• Ziprasidone

Interactions with Food/Tobacco/Alcohol

Particular medications ought to not be utilized at or around the time of eating food or eating particular sorts of food given that interactions may take place. Making use of alcohol or cigarette with certain medicines might also create communications to occur. Review with your health care professional the use of your medication with food, alcohol, or cigarette.

Other Medical Problems

The existence of various other clinical problems may affect making use of this medicine. Ensure you inform your medical professional if you have any type of other medical issues, specifically:

• Angina (upper body pain) or
• Arrhythmia (heart rhythm issue) or
• Basilar migraine headache (migraine with vision and hearing troubles), history of or
• Heart strike, history of or
• Heart or capillary disease or
• Hemiplegic migraine (migraine with some paralysis), background of or
• Hypertension (hypertension), uncontrolled or
• Ischemic digestive tract illness (bowels have reduced blood supply) or
• Liver illness, severe or
• Peripheral vascular condition (blocked arteries) or
• Stroke, background of or
• Transient ischemic strike (TIA), background of or
• Wolff-Parkinson-White Syndrome (heart rhythm issue)-- Should not be used in people with these problems.

• Bleeding problems or
• Heart rhythm issues (eg, ventricular fibrillation, ventricular tachycardia) or
• Seizures or epilepsy, background of or
• Stomach or bowel bleeding-- Use with caution. May make these conditions even worse.

• Coronary artery condition, background of or
• Diabetes or
• Hypercholesterolemia (high cholesterol in the blood) or
• Hypertension (hypertension) or
• Obesity or
• Raynaud's syndrome-- Use with caution. Might be at increased danger for more major side effects.

Together with its needed impacts, a medicine might cause some unwanted results. Although not all of these adverse effects might occur, if they do occur they may require medical interest.

Talk to your doctor quickly if any of the following negative effects take place:

Less usual

• Blurred vision
• chest discomfort or pain
• cools
• confusion
• difficult or labored breathing
• dizziness
• lightheadedness, fatigue, or impaired thinking when getting up unexpectedly from a lying or resting setting
• fainting
• quickly, pounding, or irregular heartbeat or pulse
• frustration
• nervousness
• battering in the ears
• shakiness in the legs, arms, hands, or feet
• sluggish heartbeat
• sweating
• limited feeling in the head
• rigidity or stress in the breast
• shivering or trembling of the hands or feet
• unusual fatigue or weak point

Uncommon

• Black, tarry stools
• blood in the urine
• blood in the vomit
• shedding while peing
• coughing
• decreased urination
• depression of the skin
• diarrhea
• completely dry mouth
• feeling of warmth or heat
• fever
• flushing or inflammation of the skin, specifically on the face and neck
• general sensation of discomfort or ailment
• failure to relocate the eyes
• inability to relocate the legs or arms
• rise in heart rate
• increased blinking or convulsions of the eyelid
• enhanced sensitivity to discomfort
• enhanced sensitivity to touch
• impression of the skin
• joint pain
• loss of appetite
• muscular tissue aches and discomforts
• nausea
• discomfort in the groin or genital areas
• paleness of the skin
• paleness or cool feeling in the fingertips and toes
• paralysis of one side of the body
• rapid breathing
• dripping nose
• extreme or continuing belly discomfort
• sharp back pain just listed below the ribs
• shivering
• aching throat
• standing out of the tongue
• sunken eyes
• thirst
• prickling in the hands and feet
• prickling or discomfort in the fingers or toes when subjected to cool
• difficulty resting
• problem talking or swallowing
• unchecked twisting activities of the neck, trunk, arms, or legs
• unusual facial expressions
• vomiting
• wrinkled skin

Occurrence not understood

• Agitation
• back, leg, or belly discomforts
• hemorrhaging gums
• blood in the stools
• blue color of the finger nails, lips, skin, hands, or nail beds
• changes in skin color
• modifications in vision
• lowered awareness or responsiveness
• anxiety
• double vision
• basic body swelling
• migraine, unexpected, extreme, and proceeding
• high fever
• hives or itching
• hostility
• inability to talk
• irritability
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
• loss of ability to use or recognize speech or language
• loss of appetite
• loss of awareness
• loss of vision
• migraine headache
• muscle twitching
• noisy breathing
• nosebleeds
• overactive reflexes
• discomfort, inflammation, or swelling of the foot or leg
• identify red areas on the skin
• poor coordination
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• fast weight gain
• rectal bleeding
• inflammation, soreness, or itching skin
• restlessness
• seizures
• extreme or abrupt headache
• severe sleepiness
• slurred speech
• sores, abscess, or white areas on the lips or in the mouth
• sores, welting, or sores
• tummy pain and inflammation
• swelling of the face, ankles, hands, feet, or lower legs
• puffy glands
• talking or showing enjoyment you can not control
• short-term loss of sight
• shivering or shaking
• twitching
• unexplained bleeding or wounding
• unusual blood loss or wounding
• uncommon drowsiness, dullness, or sensation of sluggishness
• abnormally cozy skin
• weak point in the arm or leg on one side of the body, unexpected and extreme
• fat burning
• yellowing of the eyes or skin

Some negative effects might happen that usually do not require medical attention. These adverse effects might disappear throughout treatment as your body gets used to the medication. Also, your healthcare specialist might have the ability to inform you about ways to stop or decrease some of these adverse effects. Get in touch with your health care expert if any of the complying with adverse effects continue or are irritating or if you have any type of inquiries regarding them:

Extra common

• Bleeding, blistering, shedding, cold, staining of the skin, sensation of stress, hives, infection, swelling, itching, swellings, tingling, discomfort, breakout, soreness, scarring, soreness, painful, swelling, inflammation, prickling, ulcer, or heat at the injection site
• burning or prickling sensation
• sleepiness
• sensation of continuous motion of self or environments
• feeling of heat
• soreness of the face, neck, arms, and sometimes, top breast
• kicked back and tranquil sensation
• experience of rotating
• sleepiness

Less typical

• Anxiety
• poor, unusual, or undesirable (after) preference
• burning, creeping, itching, pins and needles, prickling, "pins and needles", or prickling sensations
• adjustment in color vision
• adjustment in taste
• difficulty seeing during the night
• problem with moving
• pain in the jaw, nasal tooth cavity, or throat
• incorrect or unusual sense of health
• sensation weird
• heartburn
• raised level of sensitivity of the eyes to sunlight
• joint pain, tightness, or swelling
• mental complication
• muscular tissue hurting or cramping
• neck discomfort or stiffness
• red, aching eyes
• belly discomfort
• puffy joints
• tearing of the eyes
• thirst
• weak point

Uncommon

• Backache
• burping
• bloated or full sensation
• modifications in patterns and rhythms of speech
• pains
• dry heaves
• excess air or gas in the stomach or bowels
• severe thirst
• hefty bleeding
• hiccups
• hunger
• boosted thirst
• muscle exhaustion
• muscle mass twitching or jerking
• pain
• passing gas
• lowered hunger
• rhythmic movement of muscle mass
• serious belly pain with nausea and throwing up
• inflammation of the skin

Incidence not recognized

• Deafness
• panic
• severe sunburn

Opposite results not listed may likewise happen in some patients. If you see any type of various other results, get in touch with your medical care professional.

Call your physician for medical advice concerning side effects. You may report adverse effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Alsuma
• Imitrex
• Imitrex Stat Dose Refill
• Sumavel DosePro
• Zembrace Symtouch

Readily Available Dosage Forms:

• Solution
• Kit

Therapeutic Class: Antimigraine

Pharmacologic Class: Serotonin Receptor Agonist, 5-HT1

Do not use this medicine for a migraine or cluster headache that is different from your usual headaches. Instead, check with your doctor.

To relieve your migraine as soon as possible, use this medicine as soon as the headache pain begins. Even if you get warning signals of a coming migraine (an aura), you should wait until the headache pain starts before using sumatriptan.

Ask your doctor ahead of time about any other medicine you might use if sumatriptan does not work. After you use the other medicine, check with your doctor as soon as possible. Headaches that are not relieved by sumatriptan are sometimes caused by conditions that need other treatment.

If you feel much better after a dose of sumatriptan, but your headache comes back or gets worse after a while, wait at least 1 hour before using another dose. However, use this medicine only as directed by your doctor. Do not use more of it, and do not use it more often, than directed. Using too much sumatriptan may increase the chance of side effects. Do not use more than 2 doses in 24 hours.

This medicine is given as a shot under your skin (usually on the stomach, thighs, or upper arms). Sumatriptan injection may sometimes be given at home to patients who do not need to be in a hospital or clinic. If you are using this medicine at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use the medicine.

If you use this medicine at home, you will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems.

This medicine is available in 3 forms. You may use a single dose vial, prefilled syringe, or a prefilled autoinjector.

Do not use the medicine if it is dark colored or cloudy.

After you have finished injecting the medicine, be sure to follow the precautions in the patient directions about safely discarding the empty cartridge and the needle. Always return the empty cartridge and needle to their container before discarding them. Do not throw away the autoinjector unit, because refills are available.

This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form:For migraine or cluster headaches: Adults— Alsuma™, Imitrex®, and Sumavel®: 4 or 6-milligram (mg) injected under the skin. If the headache comes back after being relieved, one more dose may be injected after 1 hour. Do not use more than 2 doses of 6-mg, or 3 doses of 4-mg in any 24-hour period. Zembrace™ Symtouch™: 3 milligram (mg) injected under the skin. If the headache comes back after being relieved, one more dose may be injected after 1 hour. Do not use more than 4 doses of 3-mg in any 24-hour period. Children—Use and dose must be determined by your doctor.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away used syringes or autoinjectors in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

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