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Zimhi (injection)

Generic name: naloxone (injection)

Brand names: Narcan, Zimhi

Used for opioid overdose
Last updated November 5, 2026 0 views
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What is naloxone?

Naloxone is made use of in an emergency situation to treat a well-known or believed opioid overdose in a grown-up or kid.

This medication should not be made use of in place of emergency healthcare for an overdose.

Naloxone might also be used for functions not provided in this medication overview.

This section was rewritten for readability and reviewed for meaning.

Warnings

Naloxone is used to turn around the results of opioid medication and deal with an opioid overdose. An opioid overdose can be fatal. Signs may include serious drowsiness, identify students, sluggish breathing, or no breathing.

A person caring for you can provide the naloxone if you stop taking a breath or do not wake up. Make certain anybody caring for you understands where you keep naloxone and exactly how to use it.

Your caretaker needs to obtain emergency situation assistance after offering a naloxone injection and may require to carry out CPR (cardiopulmonary resuscitation) on you while waiting on help to show up. You may require one more injection every 2 to 3 mins up until emergency help shows up.

This section was rewritten for readability and reviewed for meaning.

Before taking this medicine

You need to not be treated with naloxone if you dislike it.

If possible prior to you receive a naloxone injection, inform your medical professional if:

  • you have heart issues.

If you utilize opioid medicine during pregnancy, your baby might be born with deadly withdrawal signs and symptoms, and may need clinical treatment for several weeks.

Using naloxone injection while you are expecting might also trigger opioid withdrawal signs and symptoms in your unborn child. Nevertheless, having an opioid overdose can be deadly to both mom and infant. It is a lot more vital to treat an overdose in the mother. You must obtain emergency situation clinical help after utilizing naloxone injection. Make certain all emergency situation clinical caretakers understand that you are expectant and any kind of follow-up doctor recognizes you obtained this medication.

Ask a physician if it is secure to nurse while using this medication.

This section was rewritten for readability and reviewed for meaning.

Naloxone side effects

Obtain emergency situation clinical help if you have indicators of an allergy: hives, hard breathing, swelling of your face, lips, tongue, or throat.

Since naloxone reverses opioid effects, this medicine may trigger sudden withdrawal signs and symptoms such as:

  • nausea or vomiting, vomiting, looseness of the bowels, belly pains;
  • fever, sneezing, sweating, body pains, weak point;
  • tremors or shuddering, quick heart price, battering heart beats, raised blood pressure;
  • goose bumps;
  • dripping nose, yawning; or
  • sensation anxious, troubled, or short-tempered.

Unexpected withdrawal signs and symptoms in a baby more youthful than 4 weeks old may be serious if not dealt with the right way. Signs and symptoms consist of uncommon sobbing, rigidity, overactive reflexes, and seizures. Call your physician or get emergency clinical aid if you are unsure just how to properly give this medication to an infant.

Usual side effects of Zimhi might include:

  • nausea or vomiting, dizziness;
  • skin redness where an injection was offered;
  • feeling lightheaded; or
  • yellowing of the skin or eyes.

This is not a complete list of adverse effects and others may occur. Call your physician for clinical guidance regarding side effects. You may report side effects to FDA at 1-800-FDA-1088.

This section was rewritten for readability and reviewed for meaning.

How is naloxone given?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Naloxone is injected into a muscle or under the skin, or into a vein. The injection may be given by a healthcare provider, emergency medical provider, or a family member or caregiver who is trained to properly give a naloxone injection.

Naloxone is injected into a vein by a healthcare provider.

If you are a caregiver or family member read all instructions when you first get this medicine. If provided, use the "trainer" device to practice giving an injection so you will know how to do it in an emergency. Ask your doctor or pharmacist if you have any questions. Seek medical help right away if an accidental needlestick injury occurs.

Be sure you know how to recognize the signs of an opioid overdose in the person you are caring for. Overdose symptoms may include:

  • slowed breathing, or no breathing;
  • very small or pinpoint pupils in the eyes;
  • slow heartbeats; or
  • extreme drowsiness, especially if you are unable to wake the person from sleep.

Even if you are not sure an opioid overdose has occurred, if the person is not breathing or is unresponsive, give the naloxone injection right away and then seek emergency medical care.

Do not assume that an overdose episode has ended if symptoms improve. You caregiver must still get emergency help after giving a naloxone injection, even if the person wakes up. You may need to perform CPR (cardiopulmonary resuscitation) on the person while you are waiting for emergency help to arrive.

Naloxone injection is given in the outer thigh. In an emergency, you may give an injection through the person's clothing.

After injecting naloxone, stay with the person and watch for continued signs of overdose. You may need to give another injection every 2 to 3 minutes until emergency help arrives. Read and carefully follow the instructions provided with this medicine.

Throw away a prefilled syringe after one use, even if there is still medicine left inside.

Store at room temperature away from moisture, heat, and light. Keep the auto-injector in its outer case until you are ready to use it.

What happens if I miss a dose?

Naloxone is made use of when needed and does not have an everyday dose.

This section was rewritten for readability and reviewed for meaning.

What happens if I overdose?

Given that naloxone is provided as the correct dose in a single-dose auto-injector, an overdose is unlikely to occur.

Prevent leaving a person alone after providing him or her a naloxone injection. An opioid overdose can impair an individual's thinking or responses.

This section was rewritten for readability and reviewed for meaning.

What other drugs will affect naloxone?

Other drugs may impact naloxone, consisting of prescription and non-prescription medications, vitamins, and herbal items. Tell your doctor regarding all other medicines you use.

This section was rewritten for readability and reviewed for meaning.

Common questions about Zimhi

Can I get free Narcan or naloxone emergency kits?
Naloxone can quickly reverse an opioid overdose and may be available free through community programs, pharmacies, or state health departments. Some nasal spray products are sold over the counter, while others require a prescription. Always call 911 after giving naloxone because emergency medical care is still needed. Continue reading
How do you administer Narcan (naloxone)?
Spray Narcan into one nostril while the person is lying on their back. Call 911 immediately, give another dose after 2 to 3 minutes if needed, and stay with the person until emergency help arrives. Narcan can restore breathing during an opioid overdose, but emergency medical care is still needed. Continue reading
Is naloxone a controlled substance?
Naloxone is not a controlled substance, according to the US Drug Enforcement Administration (DEA). It is an opioid antagonist used to treat known or suspected opioid overdose, and naloxone nasal spray (sold under the brand name, Narcan) was FDA-approved for sale over-the-counter on March 29th, 2023. It should be available for purchase in places like drug stores, convenience stores, grocery stores and gas stations, as well as online, without a prescription from late summer. Narcan Nasal Spray and naloxone is still available from the pharmacist in all 50 states without a prescription from your doctor.
Is naloxone an opioid antagonist?
Naloxone is a centrally acting opioid receptor antagonist. Naloxone binds with the highest affinity to the mu-opioid receptor subtype in the central nervous system (CNS). Naloxone works to reverse opioid overdose and a form of naloxone (Narcan nasal spray) was FDA-approved for over-the-counter (OTC) sale on 29th March 2023.
How long does Narcan (naloxone) block opiates?
Naloxone blocks opioid receptors from 30 to 120 minutes, but this can be variable and depends upon the dose and how it is given. Some patients may need repeat doses of naloxone. Continue reading
Why is fentanyl so dangerous?
Fentanyl is a powerful opioid that can be deadly when misused or taken in an overdose. It can quickly slow or stop breathing, especially in people who are not used to its effects. Combining fentanyl with alcohol, benzodiazepines, gabapentinoids, other opioids, or other depressants greatly increases the risk of overdose and death. Continue reading
What are the different types of buprenorphine/naloxone?
Buprenorphine and naloxone is a combination medicine used for the maintenance treatment of opioid dependence in adults. It is available in sublingual film and sublingual tablet dosage forms under the brand names Suboxone, Zubsolv, Bunavail (discontinued), and Cassipa (discontinued). Continue reading

Related medicines

Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
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Content is provided for education and is not medical advice. See our medical disclaimer.