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Atarax

Generic name: hydroxyzine

Brand names: Atarax (discontinued)

Last updated September 8, 2026 0 views Reviewed by Philip Thornton, DipPharm
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What is Atarax?

Atarax reduces activity in the central nervous system. It also acts as an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing and runny nose, or hives on the skin.

Atarax is used as a sedative to treat anxiety and tension. It is also used together with other medications given for anesthesia.

Atarax is also used to treat allergic skin reactions such as hives or contact dermatitis.

Atarax may also be used for purposes not listed in this medication guide.

How should I take Atarax?

Take Atarax exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take this medicine with a full glass of water.

Measure Atarax syrup with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Store at room temperature away from moisture and heat.

Warnings

You should not use Atarax if you are allergic to hydroxyzine, cetirizine (Zyrtec), or levocetirizine (Xyzal), if you have a prolonged QT interval (a rare heart problem), or if you are pregnant.

Before you take Atarax, tell your doctor if you have a seizure disorder, liver disease, or kidney disease.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Stop using Atarax and call your doctor at once if you have a serious side effect such as tremors, confusion, seizures, or restless muscle movements in your eyes, tongue, jaw, or neck.

Drinking alcohol can increase certain side effects of hydroxyzine.

Before taking this medicine

You should not use Atarax if you are allergic to hydroxyzine, cetirizine (Zyrtec), or levocetirizine (Xyzal), if you have a prolonged QT interval (a rare heart problem), or if you are pregnant.

To make sure you can safely take Atarax, tell your doctor if you have any of these other conditions:

  • epilepsy or other seizure disorder;
  • asthma, emphysema, or other breathing problem;
  • glaucoma;
  • heart disease, high blood pressure, a personal or family history of long QT syndrome, or an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);
  • stomach ulcer, blockage in your stomach or intestines;
  • thyroid disorder;
  • enlarged prostate or problems with urination;
  • liver disease; or
  • kidney disease.

Do not use Atarax without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether hydroxyzine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more likely to have side effects from this medication.

Atarax side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Atarax: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Atarax and call your doctor at once if you have a serious side effect such as:

  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • tremor (uncontrolled shaking);
  • confusion; or
  • fast or pounding heartbeats, sudden dizziness, and feeling like you might pass out;
  • seizure (convulsions).
  • a serious skin reaction--fever, skin redness, and numerous small blisters or pustules.

Less serious Atarax side effects may include:

  • dizziness, drowsiness;
  • blurred vision, dry mouth; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, nausea, vomiting, feeling like you might pass out.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol can increase certain side effects of Atarax.

What other drugs will affect Atarax?

Before using Atarax, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). Also tell your doctor if you take medicines that can affect your heart rhythm, such as antiarrhythmics, antipsychotics, antidepressants, or certain antibiotics.

This list is not complete and other drugs may interact with hydroxyzine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Common questions about Atarax

Can you take hydroxyzine for anxiety and sleep?
Yes, hydroxyzine can be prescribed short term for anxiety and anxiety‑related trouble sleeping, usually as an “as‑needed” or bridging option rather than a long‑term daily medicine. Evidence supports its short‑term anxiolytic and sedating effects, but its effectiveness and safety for chronic use beyond several months are not well established. Continue reading
Why was Atarax discontinued?
Atarax was most likely discontinued in the US due to business reasons by its manufacturer. It was not removed from the market for safety or effectiveness reasons, according to the FDA. A generic version, known as hydroxyzine hydrochloride, is available at pharmacies. Continue reading
Can Hydroxyzine be Taken Long-term For Anxiety?
Hydroxyzine is intended for short-term anxiety treatment only, typically less than 4 months. Long-term hydroxyzine use is considered off-label because no studies have examined the safety of extended use beyond this timeframe. Some research suggests a link between long-term use of medications with anticholinergic properties, such as hydroxyzine, and dementia, particularly in older adults. Brain fog has also been reported with long-term use. Continue reading
How long does hydroxyzine last?
Hydroxyzine’s noticeable calming and sedating effects typically last about 4–6 hours for most people, even though the drug itself stays in the body much longer due to an elimination half-life usually around 14–25 hours in adults and about 7 hours in children. Continue reading
Does Benadryl help with or cause anxiety?
No, Benadryl does not treat anxiety, and in some people it can cause it. Benadryl (diphenhydramine) is an allergy medicine that often makes people sleepy, so it may feel calming for a few hours. But drowsiness is not the same as treating anxiety, and Benadryl is not FDA-approved for anxiety. Continue reading
Hydroxyzine Pamoate vs HCl: What’s the difference?
Hydroxyzine pamoate and hydroxyzine HCl both deliver the same active drug, hydroxyzine, so their clinical effects (such as sedation, itch relief, and anxiety reduction) are broadly similar. The main difference is the salt form (pamoate vs hydrochloride), which influences how the medicine is formulated. Continue reading
Is hydroxyzine a controlled substance or addictive?
Hydroxyzine is not classified as a controlled substance in the United States, and current evidence does not show that it causes physical dependence or a characteristic withdrawal syndrome when stopped. It is, however, a prescription-only sedating antihistamine that should be taken only under medical supervision. Continue reading
Hydroxyzine vs Benadryl: What’s the difference?
Hydroxyzine and Benadryl (diphenhydramine) are both older, sedating H1 antihistamines, but they are different drugs with different FDA‑approved uses. Hydroxyzine is available only by prescription in the United States, while diphenhydramine (Benadryl) is sold over the counter (OTC) in many allergy and sleep products. Continue reading

Related medicines

Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
General medicine information Consumer-friendly language Source: Drugs.com

Content is provided for education and is not medical advice. See our medical disclaimer. Source page medically reviewed by Philip Thornton, DipPharm on September 8, 2026.