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Cetirizine
Generic name: cetirizine
Brand names: Zyrtec
What is cetirizine?
Cetirizine is a second generation antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Cetirizine is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose.
Cetirizine is also used to treat an allergic reaction, itching and swelling caused by chronic urticaria (hives) and minimizes or eliminates the symptoms of perennial allergic rhinitis, seasonal allergic rhinitis, chronic idiopathic urticaria, allergic asthma, physical urticaria, and atopic dermatitis.
How should I take cetirizine?
Take cetirizine exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.
You may take cetirizine with or without food.
The chewable tablet must be chewed before you swallow it.
Oral doses: measure liquid medicine (oral solution) with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever. Store cetirizine at room temperature away from moisture and heat.
Warnings
Cetirizine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of cetirizine.
Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by cetirizine.
Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever.
If you are taking cetirizine for hives, get emergency medical help immediately if you have trouble swallowing, dizziness, swelling of the tongue or around the mouth, trouble speaking, drooling, or wheezing. Cetirizine is not a substitute for an epinephrine injector. Do not use cetirizine to prevent hives from known causes such as foods, insect stings, or medicines. Call your doctor if your hives do not improve after 3 days, if they last more than 6 weeks, or if they are an unusual color, look bruised or blistered, or do not itch.
Rarely, some people have reported severe itching when stopping cetirizine after daily, long-term use of at least a few months or several years. If you experience widespread, severe itching on stopping this medication, contact your healthcare provider.
Before taking this medicine
You should not use this medication if you are allergic to cetirizine, levocetirizine, hydroxyzine, or any of the ingredients in the product.
Before taking cetirizine, tell your doctor about all of your medical conditions or if you have ever had kidney or liver disease.
Ask a health professional before using this medicine if you are pregnant. Cetirizine is not recommended if you are breast-feeding.
Cetirizine is indicated for chronic idiopathic urticaria in adults and children 6 months of age and older.
Older adults may need to take a lower than normal dose. Follow your doctor's instructions.
Cetirizine acute and common side effects
Get emergency medical help if you have any serious adverse effects or any of these signs of an allergic reaction: chronic idiopathic urticaria (hives); difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using cetirizine and call your doctor at once if you have any of these serious side effects:
- fast, pounding, or uneven heartbeat;
- weakness, tremors (uncontrolled shaking), or sleep problems (insomnia);
- severe restless feeling, hyperactivity;
- confusion;
- problems with vision; or
- urinating less than usual or not at all.
Less serious cetirizine side effects may include:
- dizziness, drowsiness;
- tired feeling;
- dry mouth;
- sore throat, cough;
- nausea, constipation; or
- headache.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.
What happens if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine or add extra doses to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have used too much of this medicine.
Overdose symptoms may include feeling restless or nervous, and then feeling drowsy.
Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by cetirizine.
Cetirizine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Avoid drinking alcohol. It can increase some of the side effects of cetirizine.
What other drugs will affect cetirizine?
There may be other drugs that can interact with cetirizine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
Common questions about cetirizine
Can you take Benadryl and cetirizine together?
Can cetirizine raise blood pressure?
Is it OK to take antihistamines every day?
Should cetirizine be taken at bedtime or upon awakening?
Which antihistamines make you drowsy?
Can you take antihistamines when pregnant?
How long does it take for cetirizine to work?
Does cetirizine make you drowsy?
How long after taking cetirizine can I drink alcohol?
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Content is provided for education and is not medical advice. See our medical disclaimer. Source page medically reviewed by Philip Thornton, DipPharm on August 13, 2026.