Capastat Sulfate (Injection)

Capreomycin injection is used along with other medicines to treat tuberculosis (TB) in patients who have not responded well to other treatments. Capreomycin is an aminoglycoside antibiotic that kills bacteria or stops them from growing.

This medicine should only be given by or under the direct supervision of your doctor.

Your doctor will monitor your progress closely while you are taking this medicine. This will help your doctor determine if the medicine is working correctly and if you should keep receiving it. Blood, urine, and hearing tests may be required to check for side effects.

Contact your doctor immediately if you experience a sudden decrease or loss of hearing, ringing in the ears, dizziness or lightheadedness, a feeling of constant movement of yourself or your surroundings, or a sensation of spinning. These may be signs of a serious hearing or balance issue.

Contact your doctor right away if you notice blood in your urine, changes in how often you urinate or the amount of urine, trouble breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling in your feet or lower legs, or weakness. These may be signs of a serious kidney issue.

In deciding to use a medicine, you and your doctor need to consider the risks versus the benefits. For this medicine, keep the following in mind:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also let your healthcare professional know if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For over-the-counter products, read the label or package ingredients carefully.

Pediatric

There have not been any appropriate studies on how age affects the effects of capreomycin injection in children. Safety and effectiveness have not been proven.

Geriatric

So far, studies have not shown any specific problems in older adults that would limit the usefulness of capreomycin injection. However, older patients are more likely to have issues with their heart, kidneys, liver, and hearing, which may need careful monitoring and possible dose adjustments for those receiving capreomycin.

Breast Feeding

There are no adequate studies in women to determine the risk to infants using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while in other cases, two different medicines may be used together even if an interaction might occur. In these cases, your doctor may change the dose, or other precautions might be necessary. While receiving this medicine, it is especially important that your healthcare professional knows if you are taking any of the medicines listed below. The following interactions have been chosen based on their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Ataluren

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alcuronium
• Aspirin
• Atracurium
• Cholera Vaccine, Live
• Cisatracurium
• Colistimethate Sodium
• Doxacurium
• Emtricitabine
• Fazadinium
• Foscarnet
• Furosemide
• Gallamine
• Hexafluorenium
• Metocurine
• Mivacurium
• Pancuronium
• Pipecuronium
• Rapacuronium
• Rocuronium
• Tacrolimus
• Tenofovir Alafenamide
• Tubocurarine
• Vecuronium

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be taken at or around the time of eating food or certain types of food due to possible interactions. Using alcohol or tobacco with certain medicines may also cause interactions. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect how this medicine works. Make sure to inform your doctor if you have any other medical issues, especially:

• Hearing problems or
• Kidney disease—Use with caution. May worsen these conditions.

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they might need medical attention.

Check with your doctor or nurse right away if any of the following side effects occur:

More common

• Black, tarry stools
• Blood in the urine
• Change in how often you urinate or the amount of urine
• Chest pain
• Chills
• Cough
• Difficulty breathing
• Dizziness
• Drowsiness
• Feeling of fullness in the ears
• Fever
• Increased thirst
• Loss of appetite
• Loss of balance
• Loss of hearing
• Nausea or vomiting
• Painful or difficult urination
• Ringing or buzzing in the ears
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Swelling of the feet or lower legs
• Swollen glands
• Trouble hearing
• Unusual bleeding or bruising
• Unusual tiredness or weakness

Rare

• Bleeding gums
• Pinpoint red spots on the skin

Incidence not known

• Confusion
• Continuous ringing or buzzing or other unexplained noise in the ears
• Decreased urine
• Dizziness or lightheadedness
• Dry mouth
• Feeling of constant movement of yourself or your surroundings
• Irregular heartbeats
• Muscle cramps in the hands, arms, feet, legs, or face
• Muscle spasms (tetany) or twitching
• Numbness and tingling around the mouth, fingertips, or feet
• Seizures
• Sensation of spinning
• Stomach cramps
• Tremor

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

• Hives or welts, itching, or skin rash
• Pain, bleeding, or hard lump at the injection site
• Redness of the skin

Other side effects not listed may also happen in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Capastat Sulfate

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Antitubercular

Chemical Class: Aminoglycoside

A nurse or other trained health professional will give you this medicine in a hospital or clinic setting. This medicine is given as a shot into a muscle or into a vein.

Missed Dose

This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.