Capreomycin (Injection)

Capreomycin (Injection) is used with other medicines to treat tuberculosis (TB) in patients who have not responded well to other treatments. Capreomycin is an aminoglycoside antibiotic that kills bacteria or stops them from growing.

This medicine should only be given by your doctor or under their direct supervision.

Your doctor will monitor your progress closely while you are taking this medicine. This will help your doctor see if the medicine is effective and decide if you should keep receiving it. Blood, urine, and hearing tests may be required to check for side effects.

Contact your doctor immediately if you experience a sudden decrease in hearing or hearing loss, ringing in the ears, dizziness or lightheadedness, a feeling of constant movement of yourself or your surroundings, or a sensation of spinning. These may indicate a serious hearing or balance issue.

Contact your doctor immediately if you notice blood in the urine, a change in how often you urinate or the amount of urine, difficulty breathing, drowsiness, increased thirst, loss of appetite, nausea or vomiting, swelling in the feet or lower legs, or weakness. These may be signs of a serious kidney issue.

In deciding to use a medicine, you and your doctor need to think about the risks and benefits. Here are some things to consider for this medicine:

Allergies

Let your doctor know if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also, inform your healthcare professional about any other allergies, including food, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

There have not been enough studies on how capreomycin injection affects children. We do not know if it is safe or effective for them.

Geriatric

Studies have not shown any specific problems for older adults that would limit the use of capreomycin injection. However, older patients are more likely to have heart, kidney, liver, and hearing issues, which may require extra caution and dose adjustments when receiving capreomycin.

Breast Feeding

There are no sufficient studies in women to determine the risk to infants when using this medication while breastfeeding. Consider the potential benefits and risks before taking this medication during breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all. In other cases, two different medicines may be used together, but your doctor may need to adjust the dose or take other precautions. It is very important that your healthcare professional knows if you are taking any of the medicines listed below. The following interactions are based on their potential significance and are not a complete list.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Ataluren

Using this medicine with any of the following medicines is usually not recommended, but it may be necessary in some situations. If both medicines are prescribed, your doctor may change the dose or how often you take one or both of the medicines.

• Alcuronium
• Aspirin
• Atracurium
• Cholera Vaccine, Live
• Cisatracurium
• Colistimethate Sodium
• Doxacurium
• Emtricitabine
• Fazadinium
• Foscarnet
• Furosemide
• Gallamine
• Hexafluorenium
• Metocurine
• Mivacurium
• Pancuronium
• Pipecuronium
• Rapacuronium
• Rocuronium
• Tacrolimus
• Tenofovir Alafenamide
• Tubocurarine
• Vecuronium

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating food or specific types of food because interactions may happen. Using alcohol or tobacco with certain medicines can also cause interactions. Talk to your healthcare professional about how to use your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems can affect the use of this medicine. Be sure to tell your doctor if you have any other medical issues, especially:

• Hearing problems or
• Kidney disease—Use with caution. May worsen these conditions.

Along with its necessary effects, a medicine may cause some unwanted effects. While not all of these side effects may occur, if they do, they may need medical attention.

Check with your doctor or nurse right away if any of the following side effects occur:

More common

• Black, tarry stools
• Blood in the urine
• Change in the frequency of urination or amount of urine
• Chest pain
• Chills
• Cough
• Difficult breathing
• Dizziness
• Drowsiness
• Feeling of fullness in the ears
• Fever
• Increased thirst
• Loss of appetite
• Loss of balance
• Loss of hearing
• Nausea or vomiting
• Painful or difficult urination
• Ringing or buzzing in the ears
• Sore throat
• Sores, ulcers, or white spots on the lips or in the mouth
• Swelling of the feet or lower legs
• Swollen glands
• Trouble with hearing
• Unusual bleeding or bruising
• Unusual tiredness or weakness

Rare

• Bleeding gums
• Pinpoint red spots on the skin

Incidence not known

• Confusion
• Continuous ringing or buzzing or other unexplained noise in the ears
• Decreased urine
• Dizziness or lightheadedness
• Dry mouth
• Feeling of constant movement of self or surroundings
• Irregular heartbeats
• Muscle cramps in the hands, arms, feet, legs, or face
• Muscle spasms (tetany) or twitching
• Numbness and tingling around the mouth, fingertips, or feet
• Seizures
• Sensation of spinning
• Stomach cramps
• Tremor

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to advise you on ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

Incidence not known

• Hives or welts, itching, or skin rash
• Pain, bleeding, or hard lump at the injection site
• Redness of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, consult your healthcare professional.

Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Capastat Sulfate

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Antitubercular

Chemical Class: Aminoglycoside

A nurse or other trained health professional will give you this medicine in a hospital or clinic setting. This medicine is given as a shot into a muscle or into a vein.

Missed Dose

This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.