Cortrosyn

Cortrosyn is a synthetic version of a hormone known as adrenocorticotropic hormone (ACTH). ACTH is a hormone that is usually made by the pituitary gland in the brain. ACTH helps the adrenal glands release cortisol and adrenaline. These hormones assist your body in dealing with stress and support several body systems, including circulation, metabolism, immunity, and the nervous system.

Cortrosyn is used in a medical test called an ACTH stimulation test. This test can assist your doctor in diagnosing adrenal gland disorders such as Addison's disease, Cushing syndrome, or hypopituitarism (when the pituitary gland does not produce hormones properly).

Cortrosyn may also be used for reasons not mentioned in this medication guide.

Before you get Cortrosyn, inform your doctor about any medical conditions or allergies you have, as well as all the medicines you are taking.

You should not be treated with Cortrosyn if you are allergic to it.

Tell your doctor if you have ever had:

• an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or
• an allergic reaction during any prior ACTH stimulation test.

It is not known whether Cortrosyn will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

Get emergency medical help if you have signs of an allergic reaction: hives; trouble breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have redness, swelling, or hives where the medicine was injected.

Common side effects of Cortrosyn may include:

• an allergic reaction;
• fast or slow heartbeats;
• increased blood pressure;
• rash; or
• swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Cortrosyn is given as an infusion into a vein. A healthcare provider will give you this injection.

Before you receive Cortrosyn, your blood will be drawn to measure your "baseline" level of certain hormones.

Your blood will be drawn again 30 to 60 minutes after Cortrosyn was injected, to measure your hormone levels and compare them to the baseline levels. This will help your doctor determine if your pituitary and adrenal functions are normal.

You may need additional medical tests to help your doctor diagnose your condition and determine how best to treat it.

Because you will receive Cortrosyn in a clinical setting, it is unlikely that you will miss a dose.

Since Cortrosyn is administered by a healthcare professional in a medical setting, an overdose is unlikely to happen.

Follow your doctor's instructions regarding any restrictions on food, drinks, or activities.

Tell your doctor about all your current medicines, especially a diuretic or "water pill."

Other drugs may affect Cortrosyn, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you begin or stop using.