Gel-One (injection)

Gel-One is like the fluid that is found around your joints. This fluid helps to lubricate and absorb shock in the joints.

Gel-One is used to treat knee pain that is a result of osteoarthritis.

Gel-One is typically given when other arthritis treatments have not worked.

Gel-One may also be used for reasons not mentioned in this medication guide.

You should not receive a Gel-One if you have an infection in your knee or in the skin around your knee.

You should not receive Gel-One if you are allergic to it, or if you have an infection in your knee or in the skin around your knee.

Gel-One is not approved for use by anyone younger than 21 years old.

Tell your doctor if you have ever had:

• blood clots or circulation problems in your legs; or
• an allergy to birds, feathers, or egg products.

It is not known whether Gel-One will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Gel-One may cause serious side effects. Call your doctor immediately if you have:

• severe pain or swelling around the knee after the injection.

Common side effects of Gel-One may include:

• warmth, pain, redness, stiffness, bruising, or swelling where the medicine was injected;
• nausea, stomach pain;
• trouble walking;
• swelling in your hands or feet;
• back pain, joint pain, muscle pain;
• numbness or tingling;
• headache, dizziness; or
• runny or stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Gel-One is injected directly into your knee joint. A healthcare provider will give you this injection.

Gel-One is usually given once every week for 3 to 5 weeks. Follow your doctor's dosing instructions very carefully.

To prevent pain and swelling, your doctor may recommend resting your knee or applying ice for a short time after your injection.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Tell your doctor if your symptoms do not improve, or if they get worse.

Call your doctor for instructions if you miss an appointment for your Gel-One injection.

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to happen.

For at least 48 hours after your injection, do not jog, do strenuous activity, or play high-impact sports like soccer or tennis. Also, do not engage in weight-bearing activities or stand for more than 1 hour at a time. Ask your doctor how long you should wait before getting back to these activities.

Other drugs may affect Gel-One, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.