Inapsine (Injection)

Droperidol injection is used to stop nausea and vomiting that might happen after surgery or diagnostic procedures.

This medicine should only be given by your doctor or someone directly supervised by your doctor.

Your doctor will check how you are doing after you receive this medicine. This will help your doctor see if the medicine is working correctly and to look for any unwanted effects.

Tell your doctor right away if you notice any changes in your heart rhythm. Symptoms may include feeling dizzy or faint, or having a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm issue like QT prolongation.

Contact your doctor immediately if you have trouble breathing, a fast heartbeat, a high fever, changes in blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or extreme tiredness. These could be signs of a serious condition called neuroleptic malignant syndrome (NMS).

Droperidol will increase the effects of alcohol and other central nervous system (CNS) depressants (medicines that can make you sleepy or less alert). Some examples of CNS depressants include antihistamines or medicines for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping pills; prescription pain medicines or narcotics; barbiturates or other seizure medications; and muscle relaxants. Check with your doctor before taking any of these medications after you receive droperidol.

In deciding to use a medicine, the risks of using the drug must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Inform your clinician if you have ever had any unusual or allergic reaction to this drug or any other drugs. Additionally tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of droperidol injection in children younger than 2 years of age. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of droperidol injection in geriatric patients. However, elderly patients are more likely to have age-related heart or kidney issues, which may require caution and an adjustment in the dose for patients receiving droperidol injection.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medicine during breastfeeding. Weigh the potential benefits against the potential chances prior to taking this medicine while breastfeeding.

Interactions with Drugs

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your physician may want to change the dose, or other precautions may be necessary. When you are receiving this medication, it is especially critical that your healthcare professional know if you are taking any of the medications listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this drug with any of the following medications is not advised. Your doctor may decide not to treat you with this medicine or change some of the other medicines you take.

• Acetophenazine
• Bepridil
• Bromperidol
• Cisapride
• Clozapine
• Dronedarone
• Levoketoconazole
• Levomethadyl
• Mesoridazine
• Molindone
• Perphenazine
• Pimozide
• Pipamperone
• Piperaquine
• Remoxipride
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Tiapride
• Triflupromazine
• Ziprasidone

Using this drug with any of the following medicines is typically not recommended, but may be required in some cases. If both medicines are prescribed together, your physician may change the dose or how often you use one or both of the medicines.

• Acecainide
• Acetazolamide
• Adagrasib
• Ajmaline
• Alfentanil
• Alfuzosin
• Alprazolam
• Amiloride
• Amiodarone
• Amisulpride
• Amitriptyline
• Amlodipine
• Amoxapine
• Anagrelide
• Apomorphine
• Aprindine
• Aranidipine
• Aripiprazole
• Aripiprazole Lauroxil
• Arsenic Trioxide
• Artemether
• Asenapine
• Astemizole
• Atazanavir
• Azimilide
• Azithromycin
• Azosemide
• Bedaquiline
• Bemetizide
• Bendroflumethiazide
• Benzhydrocodone
• Benzthiazide
• Bretylium
• Brofaromine
• Bromazepam
• Bumetanide
• Buprenorphine
• Bupropion
• Buserelin
• Butorphanol
• Calcium Oxybate
• Cannabidiol
• Cannabis
• Canrenoate
• Castor Oil
• Ceritinib
• Cetirizine
• Chloral Hydrate
• Chloroquine
• Chlorpromazine
• Chlorthalidone
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clobazam
• Clofazimine
• Clomipramine
• Clonazepam
• Clopamide
• Clorgyline
• Clothiapine
• Codeine
• Crizotinib
• Cyclobenzaprine
• Cyclothiazide
• Dabrafenib
• Daridorexant
• Dasatinib
• Degarelix
• Delamanid
• Desipramine
• Deslorelin
• Deutetrabenazine
• Dexmedetomidine
• Dibenzepin
• Dihydrocodeine
• Diltiazem
• Disopyramide
• Docusate
• Dofetilide
• Dolasetron
• Domperidone
• Donepezil
• Doxepin
• Doxylamine
• Ebastine
• Efavirenz
• Encainide
• Encorafenib
• Enflurane
• Entrectinib
• Epinephrine
• Erythromycin
• Escitalopram
• Esketamine
• Ethacrynic Acid
• Etozolin
• Etrasimod
• Felodipine
• Fendiline
• Fenquizone
• Fentanyl
• Fexinidazole
• Fingolimod
• Flecainide
• Flibanserin
• Fluconazole
• Flunarizine
• Fluoxetine
• Fluspirilene
• Fluvoxamine
• Formoterol
• Foscarnet
• Fostemsavir
• Furazolidone
• Furosemide
• Gabapentin
• Gabapentin Enacarbil
• Gallopamil
• Gatifloxacin
• Gemifloxacin
• Gepirone
• Glasdegib
• Gonadorelin
• Goserelin
• Granisetron
• Halofantrine
• Haloperidol
• Halothane
• Histrelin
• Hydrochlorothiazide
• Hydrocodone
• Hydroflumethiazide
• Hydromorphone
• Hydroquinidine
• Hydroxychloroquine
• Hydroxyzine
• Ibutilide
• Iloperidone
• Imipramine
• Indapamide
• Inotuzumab Ozogamicin
• Iproniazid
• Isocarboxazid
• Isoflurane
• Isradipine
• Ivabradine
• Ivosidenib
• Ketamine
• Ketoconazole
• Lacidipine
• Lacosamide
• Lactulose
• Lapatinib
• Lazabemide
• Lefamulin
• Lemborexant
• Lenvatinib
• Leuprolide
• Levocetirizine
• Levofloxacin
• Levorphanol
• Lidoflazine
• Linezolid
• Lithium
• Lofexidine
• Lopinavir
• Lorcainide
• Loxapine
• Lumefantrine
• Macimorelin
• Magnesium Oxybate
• Mannitol
• Mefloquine
• Meperidine
• Methadone
• Metoclopramide
• Metolazone
• Metronidazole
• Mianserin
• Mibefradil
• Mifepristone
• Mirtazapine
• Mobocertinib
• Moclobemide
• Morphine
• Morphine Sulfate Liposome
• Moxifloxacin
• Nafarelin
• Nalbuphine
• Nefazodone
• Nialamide
• Nicardipine
• Nilotinib
• Norfloxacin
• Nortriptyline
• Octreotide
• Ofloxacin
• Olanzapine
• Ondansetron
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Oxycodone
• Oxymorphone
• Ozanimod
• Pacritinib
• Paliperidone
• Panobinostat
• Pargyline
• Paroxetine
• Pasireotide
• Pazopanib
• Pentamidine
• Pentazocine
• Periciazine
• Phenelzine
• Phenobarbital
• Pimavanserin
• Piretanide
• Pirmenol
• Pitolisant
• Polythiazide
• Ponesimod
• Posaconazole
• Potassium Oxybate
• Prajmaline
• Pregabalin
• Primidone
• Probucol
• Procainamide
• Procarbazine
• Prochlorperazine
• Promethazine
• Propafenone
• Protriptyline
• Quetiapine
• Quinethazone
• Quinidine
• Quinine
• Quizartinib
• Ranolazine
• Rasagiline
• Relugolix
• Remifentanil
• Remimazolam
• Ribociclib
• Risperidone
• Ritanserin
• Ropeginterferon Alfa-2b-njft
• Selegiline
• Selpercatinib
• Sematilide
• Sertindole
• Sertraline
• Sevoflurane
• Sibutramine
• Siponimod
• Sodium Oxybate
• Sodium Phosphate
• Sodium Phosphate, Dibasic
• Sodium Phosphate, Monobasic
• Solifenacin
• Sorafenib
• Sorbitol
• Sotalol
• Spiramycin
• Spironolactone
• Sufentanil
• Sulfamethoxazole
• Sulpiride
• Sultopride
• Sunitinib
• Tacrolimus
• Tapentadol
• Tedisamil
• Telavancin
• Telithromycin
• Tetrabenazine
• Ticrynafen
• Toloxatone
• Topiramate
• Toremifene
• Torsemide
• Tramadol
• Tranylcypromine
• Trazodone
• Triamterene
• Trichlormethiazide
• Triclabendazole
• Trifluoperazine
• Trimethoprim
• Trimipramine
• Triptorelin
• Urea
• Vandetanib
• Vardenafil
• Vemurafenib
• Vilanterol
• Vinflunine
• Voclosporin
• Voriconazole
• Xipamide
• Zimeldine
• Zolmitriptan
• Zolpidem
• Zotepine
• Zuclopenthixol
• Zuranolone

Interactions with Food/Tobacco/Alcohol

Certain drugs should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this drug. Make sure you tell your doctor if you have any other medical problems, especially:

• Bradycardia (slow heartbeat) or
• Cardiac hypertrophy (heart is larger than normal) or
• Congestive heart failure or
• Heart disease or
• Hypokalemia (low potassium in the blood) or
• Hypomagnesemia (low magnesium in the blood) or
• Pheochromocytoma (adrenal gland tumor)—May cause side effects to become worse.

• Cardiac arrhythmias (abnormal heart beats) or
• Hypotension (low blood pressure)—Use with caution. May make these conditions worse.

• Congenital long QT syndrome (heart rhythm issue) or
• QT prolongation (heart rhythm problem)—Should not be used in patients with these conditions.

• Kidney disease or
• Liver disease—Use with caution. The effects may be increased since of slower removal of the medicine from the body.

Along with its needed effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they might need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

• Blurred vision
• confusion
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• sweating
• unusual tiredness or weakness

Less common

• Chills
• cough
• difficulty with breathing
• difficulty with swallowing
• dizziness
• fast heartbeat
• noisy breathing
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• skin rash, hives, or itching
• tightness in the chest

Incidence not known

• Chest pain or discomfort
• fainting
• fast, pounding, or irregular heartbeat or pulse
• irregular or slow heart rate
• low blood pressure or pulse
• severe confusion or loss of consciousness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

More common

• Anxiety
• drowsiness
• restlessness
• trouble sitting still

Incidence not known

• Difficulty with speaking
• drooling
• loss of balance control
• muscle trembling, jerking, or stiffness
• seeing, hearing, or feeling things that are not there
• shuffling walk
• stiffness of the limbs
• twisting movements of the body
• uncontrolled movements, especially of the face, neck, and back

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Inapsine

Available Dosage Forms:

• Solution

Therapeutic Class: Antiemetic

Pharmacologic Class: Dopamine Antagonist

Chemical Class: Butyrophenone

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given as a shot into a muscle or a vein.