MPI MDP (Intravenous)

Technetium Tc 99m medronate injection is a type of radiopharmaceutical. Radiopharmaceuticals are radioactive substances that can be used to detect and treat specific diseases or to examine how the body's organs work.

Technetium Tc 99m medronate injection is used to assist your doctor in viewing images of your bones to help diagnose bone issues.

This medicine should only be administered by a doctor who has specialized training in nuclear medicine or under their direct supervision.

It is very important that your doctor monitors you closely while you are receiving this medicine. This will help your doctor determine if the medicine is working properly and if you should keep using it.

While using this medicine, you may be exposed to radiation. Discuss any concerns about this with your doctor.

Before you undergo any medical tests, inform the medical doctor in charge that you are using this medicine. The results of some tests (e.g., brain imaging or scan) may be influenced by this medicine.

In deciding to use a diagnostic test, any risks of the test must be weighed against the benefits it will provide. This is a decision you and your doctor will make together. Additionally, other factors may affect test results. For this test, the following should be considered:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, let your health care professional know if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the effects of technetium Tc 99m medronate injection in children. Safety and effectiveness have not been established.

Geriatric

No information is available on the effects of technetium Tc 99m medronate injection in older adults. However, the image quality of the bone scan may be affected by aging.

Breast Feeding

Studies in breastfeeding women have shown harmful effects on infants. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Interactions with Medicines

Some medicines should not be used together at all, while in other cases, two different medicines may be used together even if an interaction might happen. In these situations, your doctor may want to adjust the dose, or other precautions may be necessary. Inform your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used around the time of eating food or certain types of food due to possible interactions. Using alcohol or tobacco with certain medicines may also lead to interactions. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect the use of this diagnostic test. Be sure to inform your doctor if you have any other medical issues, especially:

• Hypocalcemia (low calcium in the blood)—Use with caution. May worsen this condition.

• Kidney disease or
• Obesity—The image quality of the bone scan may be affected in patients with these conditions.

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they might need medical attention.

Check with your doctor or nurse right away if any of the following side effects occur:

Incidence not known

• Blurred vision
• chest pain or discomfort
• chills
• confusion
• dizziness
• dizziness, faintness, or lightheadedness when standing up suddenly from a lying or sitting position
• fainting
• fast, slow, or irregular heartbeat
• fever
• hives, itching, or redness
• lightheadedness
• nausea
• no blood pressure or pulse
• pounding or rapid pulse
• skin rash
• stopping of heart
• sweating
• unconsciousness
• unusual tiredness or weakness
• vomiting

Some side effects may happen that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you how to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue, are bothersome, or if you have questions about them:

Incidence not known

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• CIS-MDP
• MPI MDP
• Osteolite

Available Dosage Forms:

• Kit

Therapeutic Class: Diagnostic Agent, Radiopharmaceutical Imaging

A doctor or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins before you have a bone scan.

You will need to urinate right away and as often as possible for 4 to 6 hours after receiving this medicine. Drink plenty of fluids before and after receiving this medicine so you will pass more urine.