Osteolite (Intravenous)

Technetium Tc 99m medronate injection is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that can be used to find and treat certain diseases or to study how the body's organs work.

Technetium Tc 99m medronate injection helps your doctor create an image of your bones to diagnose bone issues.

This medicine should only be given by or under the direct supervision of a doctor who is specially trained in nuclear medicine.

It is very important that your doctor monitors you closely while you are receiving this medicine. This will help your doctor determine if the medicine is working correctly and decide if you should keep using it.

While using this medicine, you may be exposed to radiation. Discuss any concerns you have with your doctor.

Before undergoing any medical tests, inform the medical doctor in charge that you are using this medicine. The results of some tests (e.g., brain imaging or scan) may be influenced by this medicine.

In deciding to use a diagnostic test, any risks of the test must be weighed against the benefits. This is a decision you and your doctor will make together. Other factors may also affect test results. For this test, consider the following:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, let your health care professional know if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, carefully read the label or package ingredients.

Pediatric

Appropriate studies have not been done on how technetium Tc 99m medronate injection affects children. Safety and effectiveness have not been established.

Geriatric

There is no information on how technetium Tc 99m medronate injection affects older patients. However, age may impact the image quality of the bone scan.

Breast Feeding

Studies in breastfeeding women have shown harmful effects on infants. You should be prescribed an alternative to this medication or stop breastfeeding while using this medicine.

Interactions with Medicines

Some medicines should never be used together. In other cases, two different medicines may be used together even if an interaction could happen. In these situations, your doctor may want to adjust the dose, or other precautions might be necessary. Inform your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around mealtime or with specific foods because interactions might occur. Drinking alcohol or using tobacco with certain medicines may also lead to interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical issues may affect the use of this diagnostic test. Make sure to tell your doctor if you have any other medical problems, particularly:

• Hypocalcemia (low calcium in the blood)—Use with caution. This condition may worsen.

• Kidney disease or
• Obesity—These conditions may affect the image quality of the bone scan.

Along with its necessary effects, this medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they may require medical attention.

Contact your doctor or nurse immediately if any of the following side effects occur:

Incidence not known

• Blurred vision
• chest pain or discomfort
• chills
• confusion
• dizziness
• dizziness, faintness, or lightheadedness when getting up suddenly from lying down or sitting
• fainting
• fast, slow, or irregular heartbeat
• fever
• hives, itching, or redness
• lightheadedness
• nausea
• no blood pressure or pulse
• pounding or rapid pulse
• skin rash
• stopping of heart
• sweating
• unconsciousness
• unusual tiredness or weakness
• vomiting

Some side effects may happen that usually do not require medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your healthcare professional may also be able to provide ways to prevent or lessen some of these side effects. Check with your healthcare professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

Incidence not known

• Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• CIS-MDP
• MPI MDP
• Osteolite

Available Dosage Forms:

• Kit

Therapeutic Class: Diagnostic Agent, Radiopharmaceutical Imaging

A doctor or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins before you have a bone scan.

You will need to urinate right away and as often as possible for 4 to 6 hours after receiving this medicine. Drink plenty of fluids before and after receiving this medicine so you will pass more urine.