Papacon (Oral)

Papaverine is a type of medicine known as a vasodilator. Vasodilators help blood vessels widen, which increases blood flow. This medicine is used to treat issues caused by poor blood circulation.

You can get Papaverine only with a prescription from your doctor.

It may take some time for this medicine to work. If you feel that the medicine is not working, do not stop taking it on your own. Instead, check with your doctor.

The helpful effects of this medicine may be decreased if you smoke. If you have any questions about this, check with your doctor.

Dizziness may occur, especially when you get up from lying down or sitting or when climbing stairs. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

In deciding to use a medicine, you and your doctor need to think about the risks of taking the medicine compared to the benefits it may provide. Here are some important points to consider for this medicine:

Allergies

Let your doctor know if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, inform your healthcare professional about any other allergies you may have, such as allergies to foods, dyes, preservatives, or animals. For non-prescription products, carefully read the label or package ingredients.

Pediatric

There is no specific information comparing the use of papaverine in children to its use in other age groups. This medicine is not expected to cause different side effects or issues in children than it does in adults.

Geriatric

Papaverine may make elderly patients less tolerant to cold temperatures.

Breast Feeding

There are not enough studies in women to determine the risk to infants when using this medication while breastfeeding. Consider the potential benefits against the possible risks before taking this medication during breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others can be used together even if an interaction might happen. In these cases, your doctor may want to adjust the dose, or take other precautions. It is especially important for your healthcare professional to know if you are taking any of the medicines listed below while using this medicine. The following interactions are highlighted based on their potential importance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may choose not to treat you with this medication or change some of the other medicines you are taking.

• Bepridil
• Cisapride
• Dronedarone
• Levoketoconazole
• Piperaquine
• Riociguat
• Terfenadine

Using this medicine with any of the following medicines is usually not recommended but may be necessary in some cases. If both medicines are prescribed together, your doctor may adjust the dose or how often you take one or both of the medicines.

• Adagrasib
• Amiodarone
• Amisulpride
• Apomorphine
• Aripiprazole Lauroxil
• Atazanavir
• Buprenorphine
• Ceritinib
• Chloroquine
• Citalopram
• Clofazimine
• Clothiapine
• Clozapine
• Crizotinib
• Dabrafenib
• Dasatinib
• Deutetrabenazine
• Dexmedetomidine
• Efavirenz
• Encorafenib
• Entrectinib
• Escitalopram
• Etrasimod
• Fexinidazole
• Fingolimod
• Fluconazole
• Fluoxetine
• Formoterol
• Foscarnet
• Fostemsavir
• Gepirone
• Glasdegib
• Hydroxychloroquine
• Hydroxyzine
• Inotuzumab Ozogamicin
• Ivosidenib
• Ketoconazole
• Lefamulin
• Lenvatinib
• Leuprolide
• Lofexidine
• Macimorelin
• Methadone
• Metronidazole
• Mirtazapine
• Mobocertinib
• Nilotinib
• Olanzapine
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Ozanimod
• Pacritinib
• Paroxetine
• Phenobarbital
• Pimavanserin
• Pitolisant
• Ponesimod
• Posaconazole
• Primidone
• Quetiapine
• Quizartinib
• Relugolix
• Ribociclib
• Selpercatinib
• Sertraline
• Siponimod
• Solifenacin
• Sotalol
• Sulpiride
• Sunitinib
• Tacrolimus
• Trazodone
• Triclabendazole
• Vardenafil
• Vemurafenib
• Vilanterol
• Vinflunine
• Voclosporin
• Zuclopenthixol

Using this medicine with any of the following medicines may increase the risk of certain side effects, but taking both drugs may be the best option for you. If both medicines are prescribed together, your doctor may change the dose or how often you take one or both of the medicines.

• Ginkgo

Interactions with Food/Tobacco/Alcohol

Some medicines should not be used around mealtime or with certain foods because interactions may occur. Drinking alcohol or using tobacco with some medicines can also cause interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical issues may affect how this medicine works for you. Be sure to tell your doctor if you have any other medical problems, especially:

• Angina (chest pain) or
• Glaucoma or
• Heart disease or
• Myocardial infarction (recent heart attack) or
• Recent stroke—The risk of unwanted effects may be higher.

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, they may require medical attention.

Check with your doctor right away if any of the following side effects occur:

Rare

• Abdominal pain or tenderness
• blurred or double vision
• change in ability to see colors, especially blue or yellow
• clay-colored stools
• dark urine
• decreased appetite
• deep, slow breathing
• drowsiness
• fatigue
• fever
• headache
• insomnia
• itching
• loss of appetite
• nausea and vomiting
• painful or prolonged erection of the penis
• skin rash
• swelling of the feet or lower legs
• trouble with breathing
• unusual tiredness or weakness
• vomiting
• weakness
• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also have ways to help prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

Less common

• Constipation
• diarrhea
• dizziness or lightheadedness
• fainting
• fast, pounding, or irregular heartbeat or pulse
• feeling of constant movement of self or surroundings
• flushed face
• itching skin
• nervousness
• palpitations
• pounding in the ears
• sensation of spinning
• sleepiness or unusual drowsiness
• slow or fast heartbeat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Papacon
• Para-Time S.R.
• Pavacot

If this medicine upsets your stomach, it may be taken with meals, milk, or antacids.

For patients taking the extended-release capsule form of this medicine:

• Swallow the capsule whole. Do not crush, break, or chew before swallowing. However, if the capsule is too large to swallow, you may mix the contents with jam or jelly and swallow without chewing.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (extended-release capsules): Adults: 150 milligrams (mg) every twelve hours. The dose may be increased to 150 mg every eight hours or 300 mg every twelve hours.
• For oral dosage form (tablets): Adults: 100 to 300 milligrams (mg) three to five times a day.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.