Uses for RE-PB Hyos

Belladonna alkaloids and phenobarbital combination is used to treat cramping and spasms in the stomach and intestines. It may also be used for stomach ulcers.

This medicine is available only with your doctor's prescription.

This section was rewritten for readability and reviewed for meaning.

Precautions while using RE-PB Hyos

This medicine will increase the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, which may cause drowsiness). Some examples of CNS depressants are antihistamines or medicines for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicines; prescription pain medicines or narcotics; barbiturates; medicines for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these while you are taking this medicine.

Do not take this medicine within 1 hour of taking antacids or medicines for diarrhea. Taking them too close together will make the belladonna alkaloids less effective.

Belladonna alkaloids will often reduce sweating, which can cause your body temperature to rise. Be extra careful not to get overheated during exercise or hot weather while taking this medicine, as overheating could possibly lead to heat stroke. This is particularly important for children taking belladonna alkaloids.

This medicine may make your eyes more sensitive to light than usual. Wearing sunglasses and avoiding too much exposure to bright light may help reduce discomfort.

This medicine may cause some people to experience blurred vision or become drowsy, dizzy, or less alert than usual. Make sure you understand how this medicine affects you before driving, using machines, or doing anything else that could be dangerous if you are not alert or able to see clearly.

This medicine may lead to a dry mouth, nose, or throat. For temporary relief of mouth dryness, you can use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth remains dry for more than 2 weeks, consult your dentist. Ongoing dryness of the mouth may increase the risk of dental issues, including tooth decay, gum disease, and fungal infections.

This section was rewritten for readability and reviewed for meaning.

Before using RE-PB Hyos

In deciding to use a drug, the chances of using the medicine must be weighed against the good it will do. This is a decision you and your physician will make. For this medicine, the following should be considered:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medication or any other medications. Additionally inform your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Serious side effects may be more likely to occur in infants and children, especially those with spastic paralysis or brain damage. Unusual excitement, nervousness, restlessness, or irritability and unusual warmth, dryness, and flushing of skin are more likely to occur in children, who are normally more sensitive to the effects of belladonna alkaloids. Additionally, when belladonna alkaloids are given to children during hot weather, a rapid increase in body temperature may occur. Additionally, the barbiturate in this medication could cause some children to become hyperactive.

Geriatric

Confusion or memory loss; constipation; difficult urination; drowsiness; dryness of mouth, nose, throat, or skin; and unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in the elderly, who are typically more sensitive than younger adults to the effects of belladonna alkaloids and barbiturates. Also, eye pain may occur, which may be a sign of glaucoma.

Breast Feeding

There are no adequate studies in women for determining infant chance when using this medication during breastfeeding. Weigh the potential benefits against the potential chances before taking this medicine while breastfeeding.

Interactions with Medicines

Although certain drugs should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are using this medication, it is especially critical that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your clinician may decide not to treat you with this medicine or change some of the other medicines you take.

Ambenonium
Atazanavir
Boceprevir
Cabotegravir
Cobicistat
Darunavir
Dasabuvir
Delamanid
Doravirine
Elvitegravir
Maraviroc
Mavacamten
Nirmatrelvir
Ombitasvir
Paritaprevir
Potassium Citrate
Praziquantel
Ranolazine
Rilpivirine
Ritonavir
Rivaroxaban
Telaprevir
Tenofovir Alafenamide
Voriconazole

Using this medication with any of the following medications is typically not advised, but may be required in some cases. If both medicines are prescribed together, your clinician may change the dose or how often you use one or both of the medicines.

Abemaciclib
Abiraterone Acetate
Abrocitinib
Acalabrutinib
Acenocoumarol
Acepromazine
Aclidinium
Alfentanil
Alfuzosin
Alprazolam
Amantadine
Amifampridine
Amiodarone
Amisulpride
Amitriptyline
Amlodipine
Amobarbital
Amoxapine
Amprenavir
Anagrelide
Anileridine
Anisindione
Apalutamide
Apixaban
Apomorphine
Aprepitant
Aprobarbital
Aripiprazole
Aripiprazole Lauroxil
Armodafinil
Arsenic Trioxide
Asenapine
Astemizole
Atogepant
Atorvastatin
Atropine
Avacopan
Avanafil
Avapritinib
Avatrombopag
Axitinib
Azithromycin
Baclofen
Bedaquiline
Belladonna
Belumosudil
Benperidol
Benzhydrocodone
Benztropine
Bepridil
Bictegravir
Biperiden
Bosutinib
Brigatinib
Bromazepam
Bromocriptine
Bromopride
Brompheniramine
Budesonide
Buprenorphine
Bupropion
Buserelin
Buspirone
Butabarbital
Butalbital
Butorphanol
Cabozantinib
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Cannabis
Capmatinib
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Clarithromycin
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Clozapine
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Codeine
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Doxorubicin Hydrochloride Liposome
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Estetrol
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Fentanyl
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Voxilaprevir
Warfarin
Zaleplon
Zanubrutinib
Ziprasidone
Zolpidem
Zopiclone
Zotepine
Zuclopenthixol
Zuranolone

Using this medication with any of the following medications may cause an increased risk of certain adverse effects, but using both drugs may be the best therapy for you. If both medications are prescribed together, your doctor may change the dose or how frequently you use one or both of the medications.

Arbutamine
Betamethasone
Bexarotene
Cortisone
Digitoxin
Ethosuximide
Ginkgo
Griseofulvin
Leucovorin
Levomethadyl
Methylprednisolone
Metoprolol
Ospemifene
Prednisone
Rufinamide
Theophylline
Tiagabine
Topiramate

Interactions with Food/Tobacco/Alcohol

Certain drugs should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medications may as well cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Issues

The presence of other medical problems may affect the use of this medication. Make sure you inform your physician if you have any other medical issues, especially:

Asthma or
Dry mouth or
Emphysema (type of lung disease) or
Enlarged prostate or
Glaucoma or
Heart disease or
Hyperactivity (in children) or
Intestinal blockage or
Ulcerative colitis or
Urinary tract blockage or difficult urination—Use with caution. May make these conditions worse.

Down's syndrome—Use with caution. May make the side effects worse.

Kidney disease or
Liver disease—Use with caution. The effects may be increased since of slower removal of the medicine from the body.

This section was rewritten for readability and reviewed for meaning.

Side Effects of RE-PB Hyos

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may happen, if they do, they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Eye pain
Skin rash or hives
Sore throat and fever
Unusual bleeding or bruising
Yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Constipation
Decreased sweating
Dizziness
Dry mouth, nose, throat, or skin

Less common or rare

Bloated feeling
Blurred vision
Decreased flow of breast milk
Difficult urination
Difficulty in swallowing
Headache
Increased sensitivity of eyes to sunlight
Loss of memory
Nausea or vomiting
Unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

Antispasmodic
Belladonna/Phenobarbital
Donnatal
RE-PB Hyos
Se-Donna PB Hyos

Available Dosage Forms:

Tablet
Elixir

Therapeutic Class: Antimuscarinic Combination

Pharmacologic Class: Atropine

This section was rewritten for readability and reviewed for meaning.

Proper use of RE-PB Hyos

Take this medicine about 30 minutes to 1 hour before meals, unless otherwise directed by your doctor.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For stomach or intestine problems: For oral dosage forms (capsules or tablets): Older adults, adults, and teenagers—1 or 2 capsules 2 to 4 times a day. Your doctor may adjust the dose if needed. Children—Dose must be determined by your doctor. For oral dosage form (solution): Adults and teenagers—The usual dose is 1 to 2 teaspoons (5 to 10 milliliters (mL)) 3 or 4 times a day. Your doctor may adjust the dose if needed. Children—Dose is based on body weight and must be determined by your doctor. The usual dose is 0.5 to 7.5 mL every 4 to 6 hours. Your doctor may adjust the dose if needed. For oral dosage form (chewable tablets): Older adults, adults, and teenagers—Chew 1 or 2 tablets 3 or 4 times a day. Your doctor may adjust the dose if needed. Children 2 to 12 years of age—Chew one-half to 1 tablet 3 or 4 times a day. Your doctor may adjust the dose if needed. Children up to 2 years of age—Use is not recommended. For long-acting oral dosage form (extended-release tablets): Older adults, adults, and teenagers—1 tablet every 8 to 12 hours. Your doctor may adjust the dose if needed. Children—Use is not recommended.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Related medicines

Antispasmodic (Oral) belladonna alkaloids and phenobarbital Belladonna alkaloids and phenobarbital belladonna alkaloids and phenobarbital Belladonna/Phenobarbital (Oral) belladonna alkaloids and phenobarbital Bentyl dicyclomine (oral/injection) Cantil (Oral) mepenzolate Chlordiazepoxide and clidinium chlordiazepoxide and clidinium

Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.

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