Secreflo (Intravenous)

Secretin injection is used to stimulate the pancreas to help diagnose or find problems in the pancreas, as well as to help identify the ampulla of Vater and accessory papilla during endoscopy. It is also used to assist in the diagnosis of gastrinoma (a tumor of the bowel or pancreas).

This medicine should only be given by a doctor or under a doctor's supervision.

It is very important that your doctor check your progress at regular visits to ensure that this medicine is working properly and to look for any unwanted effects.

Do not use anticholinergic medicines together with secretin injection. This may decrease the response to pancreas stimulation testing, which may result in a false diagnosis of having a pancreas disease.

Do not use stomach medicines, such as a proton pump inhibitor and an H2 blocker, together with secretin injection. This may increase the response to pancreas stimulation testing, which may lead to a false diagnosis of having gastrinoma (tumor in the bowel or pancreas).

In deciding to use a diagnostic test, you and your doctor must consider any risks of the test against the benefits it may provide. Other factors can also affect test results. For this test, consider the following:

Allergies

Inform your doctor if you have ever had any unusual or allergic reactions to this medicine or any other medicines. Also, let your healthcare professional know about any other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies have not been done to determine how secretin injection affects children. Safety and effectiveness have not been established for this age group.

Geriatric

Studies so far have not shown any specific problems in elderly patients that would limit the usefulness of secretin injection. However, older adults may be more sensitive to the effects of this medicine compared to younger adults.

Breast Feeding

There are no adequate studies on the risk to infants when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before using this medication while breastfeeding.

Interactions with Medicines

Some medicines should not be used together at all, while others may be used together even if an interaction could happen. In such cases, your doctor may want to adjust the dose or take other precautions. It is especially important that your healthcare professional knows if you are taking any of the following medicines when you are receiving this diagnostic test. The following interactions are significant and are not a complete list.

Receiving this diagnostic test with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or frequency for one or both medicines.

• Aclidinium
• Amantadine
• Amitriptyline
• Amoxapine
• Atropine
• Belladonna
• Benztropine
• Biperiden
• Brompheniramine
• Carbinoxamine
• Carisoprodol
• Chlorpheniramine
• Chlorpromazine
• Cimetidine
• Clemastine
• Clidinium
• Clomipramine
• Clozapine
• Cyclobenzaprine
• Cyclopentolate
• Cyproheptadine
• Darifenacin
• Desipramine
• Dexlansoprazole
• Dicyclomine
• Dimenhydrinate
• Diphenhydramine
• Doxepin
• Esomeprazole
• Famotidine
• Fesoterodine
• Flavoxate
• Fluphenazine
• Glycopyrrolate
• Glycopyrronium Tosylate
• Homatropine
• Hydroxyzine
• Hyoscyamine
• Imipramine
• Ipratropium
• Lansoprazole
• Loxapine
• Meclizine
• Mepenzolate
• Nizatidine
• Nortriptyline
• Olanzapine
• Omeprazole
• Orphenadrine
• Oxitropium Bromide
• Oxybutynin
• Pantoprazole
• Paroxetine
• Perphenazine
• Pimozide
• Pipenzolate Bromide
• Pirenzepine
• Prochlorperazine
• Procyclidine
• Promethazine
• Propantheline
• Propiverine
• Protriptyline
• Rabeprazole
• Ranitidine
• Scopolamine
• Solifenacin
• Stramonium
• Terodiline
• Thioridazine
• Thiothixene
• Tizanidine
• Tolterodine
• Trifluoperazine
• Trihexyphenidyl
• Trimipramine
• Tropicamide
• Trospium
• Umeclidinium

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating food or certain types of food due to potential interactions. Using alcohol or tobacco with certain medicines may also lead to interactions. Talk with your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect the use of this diagnostic test. Be sure to inform your doctor if you have any other medical issues, especially:

• Inflammatory bowel disease or
• Vagotomy (bowel surgery)—This may lower the response to pancreas stimulation testing, leading to a false diagnosis.

• Liver disease, whether from alcohol or other causes—This may hide existing issues with the pancreas.

Along with its necessary effects, a medicine may cause some unwanted effects. Not all of these side effects may happen, but if they do, you may need medical attention.

Some side effects may occur that usually do not require medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to suggest ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

More common

• Nausea

Less common

• Feeling of warmth
• Redness of the face, neck, arms, and occasionally, upper chest
• Stomach upset
• Vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Chirhostim
• Secreflo

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Endocrine-Metabolic Agent

A doctor will give you this medicine in a hospital. This medicine is given through a needle placed into one of your veins.

You should not eat or drink for at least 12 to 15 hours before receiving this medicine.

Do not take an H2 blocker at least 2 days before receiving this medicine.