Secretin (Intravenous)

Secretin injection is used to stimulate the pancreas to help diagnose or find problems in the pancreas and to help identify the ampulla of Vater and accessory papilla during endoscopy. It is also used to assist in diagnosing gastrinoma (a tumor of the bowel or pancreas).

This medicine should only be given by a doctor or under a doctor's supervision.

It is very important that your doctor check your progress at regular visits to ensure that this medicine is working properly and to monitor for any unwanted effects.

Do not use anticholinergic medicines together with secretin injection. This may decrease the response to pancreas stimulation testing, which could result in a false diagnosis of pancreas disease.

Do not use stomach medicines, such as a proton pump inhibitor and an H2 blocker, together with secretin injection. This may increase the response to pancreas stimulation testing, which could lead to a false diagnosis of gastrinoma (tumor in the bowel or pancreas).

In deciding to use a diagnostic test, you must consider the risks of the test compared to the benefits it will bring. This decision will be made with your doctor. Other factors can also affect test results. For this test, keep the following in mind:

Allergies

Inform your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare provider know if you have any other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

There have not been appropriate studies on how secretin injection affects children. Its safety and effectiveness in this age group have not been established.

Geriatric

Studies so far have not found any specific problems in older adults that would limit the usefulness of secretin injection. However, older patients may be more sensitive to the effects of this medicine than younger adults.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medication while breastfeeding. Weigh the potential benefits against the potential risks before using this medication while breastfeeding.

Interactions with Medicines

Some medicines should never be used together, while others may be used together even if there is a possibility of interaction. In these cases, your doctor may adjust the dose, or other precautions may be necessary. When you are receiving this diagnostic test, it is especially important for your healthcare provider to know if you are taking any of the medicines listed below. The following interactions are based on their potential significance and are not necessarily all-inclusive.

It is usually not recommended to receive this diagnostic test with any of the following medicines, but it may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you take one or both of the medicines.

• Aclidinium
• Amantadine
• Amitriptyline
• Amoxapine
• Atropine
• Belladonna
• Benztropine
• Biperiden
• Brompheniramine
• Carbinoxamine
• Carisoprodol
• Chlorpheniramine
• Chlorpromazine
• Cimetidine
• Clemastine
• Clidinium
• Clomipramine
• Clozapine
• Cyclobenzaprine
• Cyclopentolate
• Cyproheptadine
• Darifenacin
• Desipramine
• Dexlansoprazole
• Dicyclomine
• Dimenhydrinate
• Diphenhydramine
• Doxepin
• Esomeprazole
• Famotidine
• Fesoterodine
• Flavoxate
• Fluphenazine
• Glycopyrrolate
• Glycopyrronium Tosylate
• Homatropine
• Hydroxyzine
• Hyoscyamine
• Imipramine
• Ipratropium
• Lansoprazole
• Loxapine
• Meclizine
• Mepenzolate
• Nizatidine
• Nortriptyline
• Olanzapine
• Omeprazole
• Orphenadrine
• Oxitropium Bromide
• Oxybutynin
• Pantoprazole
• Paroxetine
• Perphenazine
• Pimozide
• Pipenzolate Bromide
• Pirenzepine
• Prochlorperazine
• Procyclidine
• Promethazine
• Propantheline
• Propiverine
• Protriptyline
• Rabeprazole
• Ranitidine
• Scopolamine
• Solifenacin
• Stramonium
• Terodiline
• Thioridazine
• Thiothixene
• Tizanidine
• Tolterodine
• Trifluoperazine
• Trihexyphenidyl
• Trimipramine
• Tropicamide
• Trospium
• Umeclidinium

Interactions with Food/Tobacco/Alcohol

Some medicines should not be used at or around the time of eating food or certain types of food because interactions may occur. Using alcohol or tobacco with some medicines may also cause interactions. Talk to your healthcare provider about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical issues may affect the use of this diagnostic test. Be sure to inform your doctor if you have any other medical problems, especially:

• Inflammatory bowel disease or
• Vagotomy (bowel surgery)—May reduce the response to pancreas stimulation testing, leading to a false diagnosis.

• Liver disease, whether from alcohol or other causes—May hide existing pancreas issues.

Along with its needed effects, a medicine may cause some unwanted effects. Not all of these side effects may occur, but if they do, they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Your health care professional may also be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Nausea

Less common

• Feeling of warmth
• Redness of the face, neck, arms, and occasionally, upper chest
• Stomach upset
• Vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

In the U.S.

• Chirhostim
• Secreflo

Available Dosage Forms:

• Powder for Solution

Therapeutic Class: Endocrine-Metabolic Agent

A doctor will give you this medicine in a hospital. This medicine is given through a needle placed into one of your veins.

You should not eat or drink for at least 12 to 15 hours before receiving this medicine.

Do not take an H2 blocker at least 2 days before receiving this medicine.