Urea (Intravenous)

Intra-amniotic urea is injected into the uterus to induce abortion. It must only be given by your doctor or under their direct supervision.

In deciding to use a medicine, you and your doctor need to weigh the risks against the benefits of the medicine. For this medicine, consider the following:

Allergies

Inform your doctor if you have ever had an unusual or allergic reaction to this medicine or any other medicines. Also, let your healthcare professional know if you have other allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

There is no specific information comparing the use of urea in teenagers to its use in other age groups, but this medicine is not expected to cause different side effects or problems in teenagers than it does in adults.

Breast Feeding

There are no adequate studies in women to determine the risk to infants when using this medicine during breastfeeding. Weigh the potential benefits against the potential risks before taking this medicine while breastfeeding.

Interactions with Medicines

Certain medicines should not be used together at all, while in other cases, two different medicines may be used together even if an interaction might happen. In these situations, your doctor may need to adjust the dose, or other precautions may be necessary. When taking this medicine, it is especially important for your healthcare professional to know if you are taking any of the medicines listed below. The following interactions are highlighted based on their potential importance and may not include all possibilities.

Using this medicine with any of the following medicines is usually not recommended, but may be necessary in some cases. If both medicines are prescribed together, your doctor may change the dose or the frequency of use for one or both medicines.

• Amikacin
• Amikacin Liposome
• Arsenic Trioxide
• Droperidol
• Ephedrine
• Levomethadyl

Using this medicine with any of the following medicines may increase the risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Licorice

Interactions with Food/Tobacco/Alcohol

Some medicines should not be taken around the time of eating food or certain types of food due to possible interactions. Using alcohol or tobacco with certain medicines may also lead to interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other Medical Problems

Having other medical problems may affect the use of this medicine. Be sure to tell your doctor if you have any other medical issues, especially:

• Diabetes mellitus (sugar diabetes)
• Fibroid tumors of the uterus
• Kidney disease
• Liver disease
• Sickle cell disease

Along with its necessary effects, a medicine can cause some unwanted effects. Not all of these side effects may happen, but if they do, they might need medical attention.

Check with your doctor right away if any of the following side effects occur:

• Pain in lower abdomen
• weakness

Check with your doctor as soon as possible if any of the following side effects occur:

Rare

• Confusion
• irregular heartbeat
• muscle cramps or pain
• numbness, tingling, pain, or weakness in hands or feet
• unusual tiredness or weakness
• weakness and heaviness of legs

Some side effects may happen that usually do not need medical attention. These side effects may go away during treatment as your body adapts to the medicine. Your health care professional may also have ways to prevent or lessen some of these side effects. Check with your health care professional if any of the following side effects continue, are bothersome, or if you have any questions about them:

More common

• Nausea or vomiting

Less common or rare

• Headache
• diarrhea

After the procedure is completed, this procedure may still cause some side effects that need medical attention. Check with your doctor if you notice any of the following side effects:

• Chills or shivering
• fever
• foul-smelling vaginal discharge
• increase in bleeding of the uterus
• pain in lower abdomen

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Pharmacologic Class: Diuretic, Osmotic

During the abortion procedure, you should drink fluids to help prevent your body from losing too much water.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form: For causing abortion: Adults and teenagers—Up to 250 milliliters (mL) injected through the abdomen into the uterus after the same amount of fluid is taken out of the bag around the fetus (amniotic sac). The injection may be repeated 48 hours after the first dose if needed.