Sodium hyaluronate (injection)

Sodium hyaluronate is like the fluid that surrounds your joints. This fluid helps to lubricate and cushion the joints.

Sodium hyaluronate is used to relieve knee pain caused by osteoarthritis.

Sodium hyaluronate is typically given when other arthritis medications have not worked.

Sodium hyaluronate may also be used for other reasons not mentioned in this medication guide.

Sodium hyaluronate is injected straight into your knee joint. A healthcare provider will perform this injection.

Sodium hyaluronate is typically given once a week for 3 to 5 weeks. Follow your doctor's dosing instructions closely.

To help reduce pain and swelling, your doctor may suggest resting your knee or using ice for a short period after your injection.

Read all patient information, medication guides, and instruction sheets that you receive. If you have any questions, ask your doctor or pharmacist.

Let your doctor know if your symptoms do not get better, or if they worsen.

You should not receive a sodium hyaluronate injection if you have an infection in your knee or in the skin around your knee.

You should not receive sodium hyaluronate if you are allergic to it, or if you have an infection in your knee or in the skin around your knee.

Sodium hyaluronate is not approved for use by anyone younger than 21 years old.

Tell your doctor if you have ever had:

• blood clots or circulation problems in your legs; or
• an allergy to birds, feathers, or egg products.

It is not known whether sodium hyaluronate will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Sodium hyaluronate may cause serious side effects. Call your doctor right away if you have:

• severe pain or swelling around the knee after the injection.

Common side effects of sodium hyaluronate may include:

• warmth, pain, redness, stiffness, bruising, or puffiness where the medicine was injected;
• nausea, stomach pain;
• trouble walking;
• swelling in your hands or feet;
• back pain, joint pain, muscle pain;
• numbness or tingling;
• headache, dizziness; or
• runny or stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Usual Adult Dose for Osteoarthritis:

Hyalgan: 2 mL by intra-articular injection into the knee once weekly for 5 weeksSupartz: 2.5 mL by intra-articular injection into the knee once weekly for 5 weeksUse: For the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics (e.g., acetaminophen)

Call your doctor for instructions if you miss your appointment for your sodium hyaluronate (injection).

Since this medication is given by a healthcare professional in a medical setting, it is unlikely that you will receive too much.

For at least 48 hours after your injection, do not jog, do strenuous activities, or participate in high-impact sports like soccer or tennis. Also, do not engage in weight-bearing activities or stand for more than 1 hour at a time. Ask your doctor how long you should wait before returning to these activities.

Other drugs may affect sodium hyaluronate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.