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Vistaril

Generic name: hydroxyzine

Last updated September 9, 2026 0 views Reviewed by Philip Thornton, DipPharm
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What is Vistaril?

Vistaril reduces activity in the central nervous system. It also acts as an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of itching, or hives on the skin.

Vistaril is used as a sedative to treat anxiety and tension. It is also used together with other medications given during and after general anesthesia. The brand Vistaril has been discontinued but generic hydroxyzine is still available.

Vistaril is also used to treat allergic skin reactions such as hives or contact dermatitis.

How should I take Vistaril?

Take Vistaril exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Vistaril is for short-term use only.

You should not take Vistaril for longer than 4 months. Call your doctor if your anxiety symptoms do not improve, or if they get worse.

Store at room temperature away from moisture and heat.

Warnings

You should not use Vistaril if you are pregnant, especially during the first or second trimester.

Vistaril can cause a serious heart problem, especially if you use certain medicines at the same time. Tell your doctor about all your current medicines and any you start or stop using.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Stop using Vistaril and call your doctor at once if you have a serious side effect such as tremors, confusion, seizures, or restless muscle movements in your eyes, tongue, jaw, or neck.

Drinking alcohol can increase certain side effects of Vistaril.

Before taking this medicine

You should not use Vistaril if you are allergic to hydroxyzine, or if:

  • you have long QT syndrome;
  • you are allergic to cetirizine (Zyrtec) or levocetirizine (Xyzal); or
  • you are in the first trimester of pregnancy.

You should not use Vistaril if you are pregnant, especially during the first or second trimester. Hydroxyzine could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine.

To make sure Vistaril is safe for you, tell your doctor if you have:

  • blockage in your digestive tract (stomach or intestines);
  • bladder obstruction or other urination problems;
  • glaucoma;
  • heart disease, slow heartbeats;
  • personal or family history of long QT syndrome;
  • an electrolyte imbalance (such as high or low levels of potassium in your blood);
  • if you have recently had a heart attack.

It is not known whether hydroxyzine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Do not give Vistaril to a child without medical advice.

Vistaril side effects

Get emergency medical help if you have signs of an allergic reaction to Vistaril: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, Vistaril may cause a severe skin reaction. Stop taking this medicine and call your doctor right away if you have sudden skin redness or a rash that spreads and causes white or yellow pustules, blistering, or peeling.

Stop using Vistaril and call your doctor at once if you have:

  • fast or pounding heartbeats;
  • headache with chest pain;
  • severe dizziness, fainting; or
  • a seizure (convulsions).

Side effects such as drowsiness and confusion may be more likely in older adults.

Common Vistaril side effects may include:

  • drowsiness;
  • headache;
  • dry mouth; or
  • skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe drowsiness, nausea, vomiting, uncontrolled muscle movements, seizure (convulsions), or fast or pounding heartbeats.

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Drinking alcohol with this medicine can cause side effects.

What other drugs will affect Vistaril?

Taking this medicine with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking Vistaril with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Vistaril can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with hydroxyzine.

Other drugs may interact with hydroxyzine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Common questions about Vistaril

Can you take hydroxyzine for anxiety and sleep?
Yes, hydroxyzine can be prescribed short term for anxiety and anxiety‑related trouble sleeping, usually as an “as‑needed” or bridging option rather than a long‑term daily medicine. Evidence supports its short‑term anxiolytic and sedating effects, but its effectiveness and safety for chronic use beyond several months are not well established. Continue reading
Can Hydroxyzine be Taken Long-term For Anxiety?
Hydroxyzine is intended for short-term anxiety treatment only, typically less than 4 months. Long-term hydroxyzine use is considered off-label because no studies have examined the safety of extended use beyond this timeframe. Some research suggests a link between long-term use of medications with anticholinergic properties, such as hydroxyzine, and dementia, particularly in older adults. Brain fog has also been reported with long-term use. Continue reading
How long does hydroxyzine last?
Hydroxyzine’s noticeable calming and sedating effects typically last about 4–6 hours for most people, even though the drug itself stays in the body much longer due to an elimination half-life usually around 14–25 hours in adults and about 7 hours in children. Continue reading
Does Benadryl help with or cause anxiety?
No, Benadryl does not treat anxiety, and in some people it can cause it. Benadryl (diphenhydramine) is an allergy medicine that often makes people sleepy, so it may feel calming for a few hours. But drowsiness is not the same as treating anxiety, and Benadryl is not FDA-approved for anxiety. Continue reading
Hydroxyzine Pamoate vs HCl: What’s the difference?
Hydroxyzine pamoate and hydroxyzine HCl both deliver the same active drug, hydroxyzine, so their clinical effects (such as sedation, itch relief, and anxiety reduction) are broadly similar. The main difference is the salt form (pamoate vs hydrochloride), which influences how the medicine is formulated. Continue reading
Is hydroxyzine a controlled substance or addictive?
Hydroxyzine is not classified as a controlled substance in the United States, and current evidence does not show that it causes physical dependence or a characteristic withdrawal syndrome when stopped. It is, however, a prescription-only sedating antihistamine that should be taken only under medical supervision. Continue reading
Hydroxyzine vs Benadryl: What’s the difference?
Hydroxyzine and Benadryl (diphenhydramine) are both older, sedating H1 antihistamines, but they are different drugs with different FDA‑approved uses. Hydroxyzine is available only by prescription in the United States, while diphenhydramine (Benadryl) is sold over the counter (OTC) in many allergy and sleep products. Continue reading
Can dogs take hydroxyzine?
Yes, dogs can take hydroxyzine. Hydroxyzine is an antihistamine that may help treat allergies, anxiety, and motion sickness in dogs. Continue reading

Related medicines

Before you take this medicine: the information on this page is general and may not cover your personal circumstances. Read the label supplied with your medicine and ask a pharmacist or doctor if you are unsure, especially if you are pregnant, breastfeeding, taking other medicines or managing a long-term condition.
General medicine information Consumer-friendly language Source: Drugs.com

Content is provided for education and is not medical advice. See our medical disclaimer. Source page medically reviewed by Philip Thornton, DipPharm on September 9, 2026.